慢性肾衰竭患者甲状腺激素水平的变化及意义

目的探讨慢性肾衰竭患者甲状腺激素水平的变化以及临床意义。方法住院治疗的慢性肾衰竭（尿毒症期）患者79例,分为慢性肾衰竭非透析组30例;血液透析组30例;腹膜透析组19例,用电化学发光法分别检测血清FT3、FT4、sTSH水平,另选同期健康体检者作为对照。结果慢性肾衰竭非透析组、血液透析组及腹膜透析组血清FT3显著低于正常对照（2.84±0.76,3.54±0.60,3.24±1.05vs4.40±0.91pmol/L,P〈0.01）,FT4低于正常对照,但差异无统计学意义（16.77±12.31,12.81±2.89,16.51±4.51vs17.99±1.86pmol/L,P〉0.05）,sTSH高于正常对照,但差异无统计学意义（3.79±3.19,3.56±3.35,9.15±14.46vs2.62±1.35μIU/ml,P〉0.05）。慢性肾衰竭非透析组与透析组,腹膜透析组与血液透析组之间甲状腺激素各项指标变化差异无统计学意义。结论慢性肾衰竭患者常伴有甲状腺激素水平异常,表现为低T3、低T4综合征,透析不能改善慢性肾衰竭患者甲状腺激素水平异常。

The level of serum thyroid hormone in patients with chronic renal failure and Its significance

Objective To investigate the changes of serum thyroid hormone in patients with chronic renal failure(CRF) and who underwent dialysis.Methods Serum free-T3(FT3),free-T4(FT4) and thyrotropin(s-TSH) concentrations were measured by electrochemiluminescence in 79 patients with CRF,and 30 normalcontrol subjects.Results Serum levels of FT3 were significantly lower in patients with CRF than that in normal controls(P<0.01),FT4 and sTSH contents were not different compared with normal controls(P>0.05).While levels of...