羧甲基壳聚糖防粘连粉雾剂的应用及作用机制的研究

目的：探讨羧甲基壳聚糖防粘连粉雾剂在大鼠腹腔内粘连模型中的应用及其可能的作用机制。方法：将60只SD大鼠随机分成3组,即假手术组（n=20）、对照组（肠粘连模型组,n=20）和实验组（羧甲基壳聚糖组,n=20）。比较3组大鼠在术后第7天、第14天时腹腔粘连发生率和程度的影响,并用光学显微镜对大鼠腹腔内粘连标本及腹膜反应程度进行病理观察。结果：对照组各时间段发生腹腔内粘连的概率和粘连程度最高,实验组次之,假手术组最轻。结论：羧甲基壳聚糖防粘连粉雾剂能明显减少大鼠术后腹腔内粘连的发生。

Study on the effect of carboxymethyl-chitosan in the prevention of postoperative abdominal adhesion and its mechanism of action

Objective To investigate the effects of carboxymethyl-chitosan in the prevention of postoperative abdominal adhesion and its possible mechanism of action. Methods Sixty SD rats were randomly divided into 3 groups: control group 1 (open & close model) n=20, control group 2 (intestinal adhesion model) n=20 and experimental group (use of carboxymethyl-chitosan model) n=20. The degree and incidence of adhesion by the 7th day and 14th day after operation were compared respectively. The pathologic reaction of the peritoneum was observed under microscope. Results Conceming the incidence and the degree of adhesion. the control group 2 was higher than the others; in contrast the control groupl manifested the lowest degree. Conclusion Carboxymethyl-chitosan can significantly reduce the degree of postoperative adhesion in the abdomen.