癫癎儿童发作期与稳定期血清细胞因子的变化意义

目的探讨原发性癫癎患儿治疗前后血清细胞因子白细胞介素-2(IL-2)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平的变化及临床意义。方法采用酶联免疫吸附法(ELISA)对34例癫癎发作期患者、31例治疗稳定期患者及年龄、性别相匹配的35例对照者(正常儿童)血清IL-2、IL-6、TNF-α水平进行测定。结果癫组血清IL-2、IL-6和TNF-α水平均高于对照组,且发作组高于稳定组(P<0.01)。结论癫癎患者的免疫系统处于活化状态,细胞因子水平的失衡参与了癫癎的免疫病理过程。

Changes of cytokine levels of peripheral blood in children with epilepsy of different periods

Objective To investigate the changes of interleukin-2(IL-2),interleukin-6(IL-6) and tumor necrosis factor alpha(TNF-α) in epileptic patients of different periods,and to definite their roles in the pathogenesis of epilepsy.Methods Serum contents of IL-2,IL-6 and TNF-α were determined by ELISA in 34 epilepsy patients of onset and 31 stable phase epilepsy patients,and 35 healthy children with regard to age and sex as control.Results The levels of all three cytokines were significantly higher in epileptic group than that of control group,and epileptic patients on the period of onset were significantly higher than those patients in the stable phase(P<0.01).Conclusion The immune system of children with epilepsy is in an activated state.The imbalance of cytokines level may be involved in immunopathologlogy of epilepsy.