胃癌患者凝血指标检测及临床意义

目的 探讨胃癌患者凝血指标的变化与肿瘤侵犯深度、淋巴结转移及临床分期的关系。方法 收集2014年1月至12月的120例胃癌患者并检测其凝血指标：凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（Fib）、D-二聚体（DD）和血小板（PLT）。并以同期60例健康体检者作为对照，比较两组间凝血指标的差异，并分析凝血指标和胃癌肿瘤侵犯深度、淋巴结转移及临床分期的关系。结果 与对照组相比，胃癌组Fib、DD、PLT均明显升高，差异有统计学意义（P＜0.05）；而两组APTT、TT、PT水平的差异无统计学意义（P＞0.05）。胃癌患者中，T2～T4期与T1期比较，N1～N3期与N0比较，Ⅳ期与Ⅰ～Ⅲ期比较，Fib、DD、PLT均明显升高，差异有统计学意义（P＜0.05）。结论 胃癌患者的凝血功能明显变差，同时其凝血功能与胃癌的分期、浸润深度及淋巴结转移密切相关。

Detection of tumor coagulation indexes in patients with gastric cancer and their clinical significance

Objective To investigate the association between coagulation detection and tumor invasion, nodal status, staging in patients with gastric cancer.Methods From Jan 2014 to Nov 2014, a total of 120 patients with gastric cancer as the experimental group and 60 healthy volunteers as control were enrolled to receive coagulation index detection.The test items included prothrombin time (PT), activated partial clotting enzyme live time (APTT), thrombin time (TT), fibrinogen (Fib), D-dimer (DD) and platelet (PLT).We compared the difference of the blood coagulation indexes of both groups and analyzed the correlation between these blood coagulation indexes and the depth of tumor invasion, lymph node metastasis, and clinical staging.Results Compared with control group, Fib, DD and PLT were significantly higher in gastric cancer group with statistical significant (P<0.05), while APTT, TT and PT were not significantly different between both group (P>0.05).In gastric cancer patients, T2-T4 staging compared to T1 staging, N1-N3 staging compared to N0 staging, and Ⅳ staging compared to Ⅰ-Ⅲ staging, Fib, D-D, PLT were significantly elevated with statistical difference (P<0.05).Conclusion Compared with the healthy volunteers, blood coagulation function of patients with gastric cancer significantly deteriorated.The blood coagulation function is closely related to the depth of tumor invasion, clinical staging and lymph node metastasis.