乌鲁木齐地区非酒精性脂肪肝患病率及危险因素分析

目的探讨新疆乌鲁木齐地区非酒精性脂肪肝(NAFLD)的患病特点及危险因素。方法 2574例体检者资料为研究对象,将研究对象分为NAFLD组和非NAFLD组,分析两组的生化指标及相关疾病患病率,采用多因素Logistic回归分析评价NAFLD的危险因素。结果本研究NAFLD总患病率为36.13%,在60~69岁组最高,男性患病率高于女性。NAFLD组的年龄、体质量指数、舒张压、收缩压、腰围、臀围、腰臀比、丙氨酸氨基转移酶(ALT)、尿酸(UA)、空腹血糖(FBG)、糖化血红蛋白、总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)值均较非NAFLD组高。NAFLD组高TG、高TC、低高密度脂蛋白胆固醇、高LDL-C、高血压、空腹血糖调节受损或糖尿病、肥胖、高尿酸血症及肝功能异常的患病率高于非NAFLD组。多因素Logistic回归结果显示性别、年龄、SBP、ALT、FBG、UA、TG及LDL-C与NAFLD密切相关,为NAFLD的危险因素。结论乌鲁木齐地区NAFLD的患病率较高,较前有增加趋势;与肥胖、血脂异常、血糖代谢紊乱、高血压、高尿酸血症等多种代谢紊乱相关。

Prevalence and risk factor of non-alcoholic fatty liver disease in Xinjiang Urumqi region

Objective To explore the clinical characteristics and risk factors of NAFLD in Xinjiang Urumqi region.Methods A total of 2574 healthy subjects were included.The patients were divided into two groups (NAFLD and non-NAFLD group) and compared their clinical characteristics,biochemical index and related diseases prevalence.Multiple logistic regression was used to the risk factors of NAFLD.Result The overall prevalence of NAFLD was 36.13％.The prevalence of male was higher than female.The prevalence of 60-69 group was the highest.In NAFLD group,age,body metabolism index,systolic blood pressure,diastolic blood pressure,waist circumference,hip circumference,waist hip ratio,alanine aminotransferase,uric acid,fasting blood glucose,glycosylated hemoglobin,triglycerides,total cholesterol,low density lipoprotein cholesterol were higher than those of control group.Compared with control group,hyper-total cholesterol,hypertriglycerides,low high-density lipoprotein cholesterol hyperlipidemia,high low-density lipoprotein cholesterol hyperlipidemia,hypertension,impaired fasting blood glucose regulate or diabetes,obesity,hyperuricemia and abnormal liver function prevalence rate in NAFLD group were higher.The multiple logistic regression analysis showed that:sex,age,SBP,ALT,FBG,UA,TC and HDL-C were the independent risk factor of NAFLD.Conclusion Compared with the prevalence of NAFLD in urumqi had a raise trend,which is related to these metabolic disorders including obesity,dyslipidemia,glucose metabolism disorders,hypertension,hyperuricemia and etc.