Promotion by SR 48692 of gastric emptying and defaecation in rats suggesting a role of endogenous neurotensin. |
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| Authors: | T. Croci A. Giudice L. Manara D. Gully G. Le Fur |
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| Affiliation: | SANOFI-Midy S.p.A. Research Center, Milan, Italy. |
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| Abstract: | We investigated the influence of the nonpeptide neurotensin receptor antagonist, SR 48692, administered orally, on gastric emptying and on acute defaecation. SR 48692 dose-dependently (ED50 approximately 0.7 microgram kg-1) increased gastric emptying of a food suspension, but it had no effect on that of a non-caloric meal. SR 48692 also dose-dependently promoted defaecation and increased faecal water content. We suggest that antagonism of endogenous neurotensin accounts for the gastric emptying and defaecation promoting action of SR 48692. |
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