Altered in vitro immune response to hypoxia-treated normal peritoneal fibroblasts |
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| Authors: | Alpay Zeynep Ozgönenel Melike Savaşan Süreyya Buck Steven Saed Ghassan M Diamond Michael P |
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| Affiliation: | a Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit, Michigan
b Division of Hematology/Oncology, Carman Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan |
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| Abstract: | Hypoxia treatment of normal peritoneal fibroblasts results in alterations that are characteristic for fibroblasts obtained from postoperative peritoneal adhesion tissue. In this study, we have shown that hypoxia treatment enhances normal peritoneal fibroblast elimination by lymphokine-activated killer cells to the level of adhesion tissue fibroblasts, suggesting a pivotal role of hypoxia in the adhesion development. |
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