窄谱UVB联合阿维A治疗斑块型银屑病疗效观察

目的观察311 nm窄谱中波紫外线(NB-UVB)联合阿维A治疗斑块型银屑病的疗效。方法单独采用NB-UVB照射、单独应用阿维A治疗及NB-UVB联合阿维A治疗斑块型银屑病90例,以银屑病皮损面积和严重度指数(PASI)评价疗效。结果三组在(26.16±4.37)天、(28.24±5.27)天、(18.34±3.52)天治疗后,三组治疗前后PASI评分改善率分别为(77.65±24.77)%,(78.64±23.43)%,(89.44±25.57)%;与阿维A治疗组比较,NB-UVB照射组与其疗效相当(P>0.05),而NB-UVB联合阿维A治疗组则在更短的治疗时间(P<0.05)取得了更好的疗效(P<0.05)。结论NB-UVB联合阿维A治疗斑块型银屑病疗效好,不良反应少。

Observation of the Efficacy of Narrow-band Ultraviolet B Phototherapy Combined with Acitretin on Psoriasis Plaque

Objective To observe the efficacy of narrow-band ultraviolet B(NB-UVB) in the treatment of patients with psoriasis plaque.Methods A total of 90 patients were treated by 311nm narrow-band ultraviolet B radiation only,acitretin only or narrow-band ultraviolet B radiation combined with acitretin.Results The efficacy was evaluated by psoriasis area and severity index(PASI),After (26.16±4.37)d,( 28.24±5.27)d and (18.34±3.52)d treatment,the improved rates of PASI of NB-UVB group,acitretin group,NB-UVB combined acitretin group were(77.65±24.77)%,(78.64±23.43)% and (89.44±25.57)%, respectively.When compared with acitretin group,the efficacy of NB-UVB group had no difference(P>0.05),while NB-UVB combined acitretin group got better efficacy(P<0.05) in shorter time(P<0.05).Conclusion Radiation of NB-UVB combined with acitretin is safe and can improve the efficacy significantly for psoriasis plaque.