| α-硫辛酸对糖尿病周围神经病变氧化应激和内皮功能的影响 |
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| 引用本文： | 潘晓燕,郑景晨,龚小花,陈以勒,沈飞霞,汪大望. α-硫辛酸对糖尿病周围神经病变氧化应激和内皮功能的影响[J]. 中华糖尿病杂志, 2009, 17(5): 372-373 |
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| 作者姓名： | 潘晓燕 郑景晨 龚小花 陈以勒 沈飞霞 汪大望 |
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| 作者单位： | 潘晓燕,郑景晨,龚小花,沈飞霞,汪大望(温州医学院附属第一医院内分泌科,浙江,325000);陈以勒(温州医学院附属第一医院检验科,浙江,325000) |
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| 摘 要： | 目的观察α-硫辛酸（ALA）对2型糖尿病患者周围神经病变（DPN）氧化应激和内皮功能的影响。方法30例DPN患者予ALA600mg／d静脉滴注14天。检测治疗前后氧化应激功能指标和血管细胞黏附分子（VCAM-1）、细胞间黏附分子（ICAM1）的水平。结果ALA可抑制氧化应激功能，降低ICAM-1的水平升高超氧化物歧化酶（SOD）活力，降低丙二醛含量，差异均有统计学意义，VCAM-1治疗前后差异无统计学意义。结论ALA可抑制DPN患者氧化应激功能及降低ICAM-1水平。
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| 关 键 词： | α-硫辛酸 糖尿病神经病变 氧化应激 细胞间黏附分子 血管细胞黏附分子 |
Effect of alpha-lipoic acid on oxidative stress and endothelial function in patients with diabetic peripheral neuropathies |
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| Affiliation: | PAN Xiao-yan, ZHENG Jing-chen, GONG Xiao-hua, et al. (The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000 ,China) |
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| Abstract: | Objective To observe the effects of alpha-lipoic acid on oxidative stress and endothelial function in patients with diabetic peripheral neuropathies. Methods 30 subjects were treated with alpha-lipoic acid 600mg daily intravenously for fourteen days. Oxidative stress indexes and levels of VCAM-1 and ICAM-1 were measured before and after the treatment. Results Alpha-lipoic acid inhibited oxidative stress and decreased ICAM-1 level. There was a significant increase in SOD level（P〈0.01） and a significant decreased level of MDM（P〈0.05）and ICAM-I （P〈0.01）. VCAM-1 level was decresed, but there was no significant difference （P〉0.05）. Conclusions Alpha-lipoic acid can inhibit the oxidative stress and decrease the level of ICAM-1 in patients with diabetic peripheral neuropathies. |
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| Keywords: | Atpha-lipoic acid Diabetic neuropathy Oxidative stress Intercellular adhesion moleeule-1 Vascular cell adhesion molecular-1 |
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