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Subtypes of HLA-B27 detected by cytotoxic T lymphocytes and their role in self-recognition |
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| Authors: | M H Breuning C J Lucas B S Breur M Y Engelsma G G de Lange A J Dekker W E Biddison P Ivanyi |
| Institution: | a Central Laboratory of the Netherlands, Red Cross Blood Transfusion Service, and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, The Netherlands b Jan van Breemen Institute, Amsterdam, The Netherlands c The Immunology Branch, National Institutes of Health, Bethesda, Maryland, The Netherlands |
| Abstract: | In the present study cytotoxic T lymphocytes were generated in MLC of lymphocytes from two unrelated HLA-A, B, C-identical, B27-positive, but D/DR-different, individuals. These CTL were shown to detect subtypes of HLA-B27. CTL specific for influenza virus lysed infected target cells matched for HLA-B27 only when they shared the same subtype. This indicates that the two subtypes of HLA-B27 detected by CTL function also as distinct elements in a self-restricted CTL response. Both subtypes were found among patients with ankylosing spondylitis. |
| Keywords: | MHC major histocompatibility complex MLC mixed lymphocyte culture CTL cytotoxic T lymphocyte |
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