| 多孔碳酸钙陶瓷生物安全性评价 |
| |
| 引用本文： | 徐晶,谭金海,魏任雄,熊健,熊亮. 多孔碳酸钙陶瓷生物安全性评价[J]. 武汉大学学报(医学版), 2006, 27(5): 624-625,652 |
| |
| 作者姓名： | 徐晶 谭金海 魏任雄 熊健 熊亮 |
| |
| 作者单位： | 武汉大学中南医院骨科,武汉,430071;武汉大学中南医院骨科,武汉,430071;武汉大学中南医院骨科,武汉,430071;武汉大学中南医院骨科,武汉,430071;武汉大学中南医院骨科,武汉,430071 |
| |
| 摘 要： | 目的:探讨多孔碳酸钙陶瓷(PCCC)的生物相容性,为临床应用提供实验依据。方法:采用浸提法制备PCCC生理盐水,实验项目包括急性毒性实验、微核实验、肌肉内植入实验。结果:PCCC无致基因突变的作用,植入体内后组织学检查未见免疫排斥反应,只出现一过性的炎症反应,对肌肉无刺激作用。结论:PCCC具有良好的生物相容性,适合于作为骨缺损的填充材料。
|
| 关 键 词： | 碳酸钙 陶瓷制品 骨替代品 生物相容性 |
| 文章编号： | 1671-8852（2006）05-0624-02 |
| 收稿时间： | 2006-03-18 |
| 修稿时间： | 2006-03-18 |
Biocompatibility Evaluation of Porous Carbonate Calcium Ceramics |
| |
| XU Jing,TAN Jinhai,WEI Renxiong,XIONG Jian,XIONG Liang. Biocompatibility Evaluation of Porous Carbonate Calcium Ceramics[J]. Medical Journal of Wuhan University, 2006, 27(5): 624-625,652 |
| |
| Authors: | XU Jing TAN Jinhai WEI Renxiong XIONG Jian XIONG Liang |
| |
| Affiliation: | Dept. of Orthopedics,Zhongnan Hospital of Wuhan University ,Wuhan 430071 , China |
| |
| Abstract: | Objective: To study the biocompatibility evaluation of porous carbonate calcium ceramics(PCCC) and to provide experiment basis for the clinical application.Methods: PCCC was immersed into physiological saline and culture fluid to acquire PCCC solution,the experiments include acute toxicity testing,minute nucleus test and muscle implant test.Results: PCCC had no gene mutation,and no significant immune reaction of foreign body was observed by histochemistry technique after it was implanted into muscular pocket.Conclusion: According to the tests,the porous carbonate calcium ceramics showed no inflammatory reaction and good tissue biocompatibility. |
| |
| Keywords: | Carbonate Calcium Ceramics Bonesubstitute Biocompatibility |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
