小白鼠脏器活性巯基分布

为了解活性巯基在小白鼠脏器中分布规律 ,测定了一组正常小白鼠各脏器活性巯基含量。在包括肝、肾、心、脾、脑和肺在内的 6种脏器中 ,肝脏含活性巯基最高 ,为 450 .2 9± 73.38mg/kg,这些脏器活性巯基含量顺序依次为肝 >肾 (30 1 .1 7± 54.1 9mg/kg) >脾、心、脑 (分别为 2 67.43± 47.33、2 63.2 9± 48.2 3及 2 54.1 1± 49.87mg/kg) >肺 (2 2 6.74± 46.2 8mg/kg)。2 3～ 2 4周龄小白鼠各脏器活性巯基含量高于 5～ 6周龄及 35～ 36周龄组。动物性别间未发现巯基含量差异。结果提示肝脏高活性巯基含量在机体内源性或外源性毒素解毒中可能起到重要作用。

Distribution of Active Thiol-group in Viscera of mouse

In order to understand the law of distribution of active thiol-group in Viscera the content of acfive thiol-group in Viscera were tested in a group of normal mice.Among six Viscera,which included liver,kidney,heart,lung,spleen and brain,the liver contained a level of active thiol-group of 450.29±73.38 mg/kg,and it was the highest one in these viscera tested.The order of the levels of thiol-group in these viscera was as following:liver>kidney (301.17±54.19 mg/kg)>spleen,heart and brain(267.43±47.33,263.29±48.23,and 254.11±49.87 mg/kg)>lung(226.74±46.28 mg/kg).The content of active thiol-group of each viscous in the group of 23～24 weeks old was higher that in the group of 5～6 weeks old and the group of 35～36 weeks old,respectively.No difference was found in both sexes.The results suggest that the high level of active thiol-group in liver may play an important role to detoxification for some exogenous of endogenous toxins.