|
|||||
|
|
| 小窝蛋白-1与血小板反应蛋白在肾透明细胞癌中的表达及其意义 | |
| 引用本文： | 蓝建发,陈一戎,潘华,史葆光,段国兰.小窝蛋白-1与血小板反应蛋白在肾透明细胞癌中的表达及其意义[J].现代泌尿外科杂志,2009,14(3):189-192. |
| 作者姓名： | 蓝建发 陈一戎 潘华 史葆光 段国兰 |
| 作者单位： | 1. 兰州大学第二医院妇产科 2. 甘肃省人民医院泌尿外科 3. 兰州大学遗传学教研室 4. 兰州大学第二医院病理科,甘肃兰州,730000 |
| 摘 要： | 目的研究小窝蛋白-1（CAV-1）和血小板反应蛋白（TSP）在肾透明细胞癌、癌旁组织、正常组织中的表达并探讨二者关系。方法应用免疫组织化学SP法对38例肾透明细胞癌、癌旁、正常组织中的CAV-1和TSP进行检测。结果CAV-1在肾透明细胞癌组织中表达明显高于其在癌旁、正常组织肾小管和肾小球中表达，三者呈递减关系，其差异有统计学意义（P〈0．001）；TSP在肾透明细胞癌中呈低表达，在正常组织肾小管中则呈高表达。CAV-1在肾透明细胞癌组织中的高表达，与肾透明细胞癌的组织学分级、临床分期密切相关，与TSP的低表达恰好相反，但两者之间的相关性无统计学意义（P〉0．05），可能是两个独立的指标。结论CAV-1可能是促进肾透明细胞癌侵袭、生长及导致不良预后的一个潜在的因子。 |
| 关 键 词： | 肾透明细胞癌 小窝蛋白-1 血小板反应蛋白 |
Expression and significance of caveolin-1 and thrombospondin in renal clear cell carcinoma |
|
| LAN Jian-fa,CHEN Yi-rong,PAN Hua,SHI Bao-guang,DUAN Guo-lan.Expression and significance of caveolin-1 and thrombospondin in renal clear cell carcinoma[J].Journal of MOdern Urology,2009,14(3):189-192. | |
| Authors: | LAN Jian-fa CHEN Yi-rong PAN Hua SHI Bao-guang DUAN Guo-lan |
| Institution: | 1.Department of Gynecology and Obstetrics;the Second Hospital of Lanzhou University;2.Department of Urology;Gansu Provincial People's Hospital;3.Department of Genetics Teaching and Research;Lanzhou University;4.Department of Pathology;Lanzhou 730000;China |
| Abstract: | Objective To study the expression of CAV-1 and TSP in renal clear cell carcinoma(CCRCC),peritumoral tissues and normal renal tissues and their biological significance.Methods The expression of CAV-1 and TSP was detected by SP immunohistochemical method in 38 cases of CCRCC,peritumoral tissues and normal renal tissues who had undergone radical nephrectomy.Results CAV-1 had higher expression in CCRCC than in peritumoral tissue or normal renal tissues.However,the expression of TSP was adverse in CCRCC.The expr... |
| Keywords: | renal clear cell carcinoma CAV-1 thrombospondin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |