Pharmacology of Cephalothin in the Biliary Tract of Humans |
| |
| Authors: | J. Mendelson J. Portnoy H. Sigman V. Dick |
| |
| Affiliation: | Department of Microbiology, Medicine and Surgery, and the Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, Quebec, Canada |
| |
| Abstract: | Serum and biliary tract levels of cephalothin were determined in a large series of patients. Serum cephalothin levels in the therapeutic range were present at 1 h after a single dose of the antibiotic in only 4 of 39 (10.3%) subjects. Therapeutic bile cephalothin levels were achieved in only 2.4% of all subjects, and this occurred between 40 and 70 min after the administration of the antibiotic. |
| |
| Keywords: | |
|
|
