厄贝沙坦对动脉粥样硬化斑块消退的影响

目的探讨厄贝沙坦消退粥样斑块的机制。方法将40只实验兔随机分为正常对照组10只和实验组30只，正常对照组喂普通饲料，而实验组喂高脂饲料12周后，改喂普通饲料并随机分为自然消退组、辛伐他汀组和厄贝沙坦组各10只，分别给予辛伐他汀和厄贝沙坦治疗12周。测定血清血脂浓度及斑块内膜和中膜厚度, 免疫组化法检测斑块内血管细胞粘附分子 1(VCAM 1)、成纤维细胞生长因子2(FGF2)和Bcl 2蛋白的表达。结果与自然消退组相比,厄贝沙坦组的血脂无统计学差异（P>0.05）,其斑块内膜厚度、内膜/中膜及VCAM 1、FGF2的表达均降低，Bcl 2的表达增加(P均<0.05)。结论厄贝沙坦可能通过影响VCAM 1、FGF2和Bcl 2的表达而消退斑块。

Effects of irbesartan on regression of atherosclerotic plaque

To explore the therapeutic effects and mechanisms of irbesartan on regression of atherosclerotic plaque (AP). Methods40 rabbits were divided into the control group（n=10）and the experimental group(n=30). The control group was fed with a normal diet, while the experimental group was fed with a cholesterol diet for 12 weeks, then was fed with a normal diet and divided into the regression control group (n=10), the simvastatin group (n=10) and the irbesartan group (n=10), which were respectively administrated with simvastatin and irbesartan for 12 weeks. Levels of plasma lipids, intima thickness and media thickness of AP were determined. Expressions of VCAM 1, FGF2 and Bcl 2 in AP were determined by immunohistochemical technique. ResultsCompared with the regression control group, ① there was no significant effect on levels of plasma lipids in the irbesartan group(P>0.05); ② The intima thickness, intima thickness/media thickness and expressions of VCAM 1 and FGF2 were significantly decreased and those of Bcl 2 were prominently increased in the irbesartan group（P<0.05）. ConclusionIrbesartan has a potential antiatherogen effect by influencing expressions of VCAM 1, FGF2 and Bcl 2.