放射性核素标记生长抑素类似物在淋巴瘤中的应用

生长抑素类似物如奥曲肽、depreotide等与生长抑素受体作用时间长、亲和力高,并可被放射性核素标记,用于肿瘤的生长抑素受体显像和治疗。淋巴瘤细胞表达该受体,因此可利用生长抑素受体对其进行显像和治疗。大量临床和实验研究均表明,放射性核素标记生长抑素类似物的生长抑素受体显像可对淋巴瘤进行诊断、分期、治疗和预后的评价,也可作为常规影像学显像、67Ga和PET显像诊断、评价淋巴瘤的一种有力补充。而在淋巴瘤治疗中的应用应当慎重,如何能获得最佳治疗效果而又将其副作用减小到最低程度是今后研究的主要课题之一。

The role of radionuclide-labeled somatostatin analogues in lymphoma

Somatostatin analogues, such as octreotide, depreotide and so on, having long-time and high affinity with somatostatin receptors(SSTR) and labeled by radionuclides, can be used in SSTR scintigraphy and treatment of tumors expressing SSTR. Moreover, Lymphoma express SSTR(SSTR2 and SSTR3). A series of clinical and experimental results showed SSTR scintigraphy is an interesting way to evaluate the diagnosis, staging, treatment and prognosis of lymphoma, and a supplemental tool of diagnosing and judging lymphoma with conventional X-rays imaging, 67Ga and PET. Whereas, the application of radionuclide-labeled somato-statin analogues in treatment of lymphoma should be cautiously performed. Recently it is a concerned ques-tion how the patients suffering from lymphoma can have the most profits and the least side-effects from the treatment of radionuclide-labeled somatostatin analogues.