| 丹参酮ⅡA磺酸钠对大鼠心，脑微粒体Na~＋，K~＋－ATP酶的抑制作用 |
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| 引用本文： | 王幼林,陈念航,丁建花.丹参酮ⅡA磺酸钠对大鼠心，脑微粒体Na~＋，K~＋－ATP酶的抑制作用[J].中国药理学与毒理学杂志,1994(1). |
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| 作者姓名： | 王幼林 陈念航 丁建花 |
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| 作者单位： | 南京医科大学药理教研室 |
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| 摘 要： | 丹参酮ⅡＡ磺酸钠（ＤＳ－２０１）体外可逆性抑制大鼠心，脑微粒体Ｎａ＋，Ｋ＋ＡＴＰ酶。并具有浓度依赖性，且对心微粒体Ｎａ＋，Ｋ＋－ＡＴＰ酶的抑制作用较扯降低Ｎａ＋或ＡＴＰ浓度则增强或减弱其抑酶作用，动力学分析表明ＤＳ－２０１对脑微粒体Ｎａ＋，Ｋ＋－ＡＴＰ酶的作用近似Ｎａ＋的竞争性拮抗剂，ＡＴＰ的反竞争性拮抗剂，有Ｋ＋及Ｍｇ２＋存在时则表现为非竞争性或混合型抑制，但对心肌微粒体Ｎａ＋，Ｋ＋－ＡＴＰ酶的作用则略有差别。
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| 关 键 词： | 磺酸类 丹参酮 钠 钾腺苷三磷酸酶 心脏 脑 微粒体 |
Inhibitory effects of sodium tanshinone Ⅱ A sulphonate onmicrosomal Na+, K+-ATPase in rat heart and brain |
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| WANG You-Lin,CHEN Nian-Hang, DINGJian-Hua.Inhibitory effects of sodium tanshinone Ⅱ A sulphonate onmicrosomal Na+, K+-ATPase in rat heart and brain[J].Chinese Journal of Pharmacology and Toxicology,1994(1). |
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| Authors: | WANG You-Lin CHEN Nian-Hang DINGJian-Hua |
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| Abstract: | The effects of sodium tanshinoneⅡ A sulphonate (DS-201) on the microsomal Na+,K+-ATPase from hearts and brains of rats were investi-gated in vilro. DS-201 inhibited the enzyme quicklyand reversibly. The inhibition was in a concentration-dependent manner and stronger on heart enzyme thanon that of brain. The DS-201 inhibition was enhancedat low Na+, but weakened at low ATP. Kinetic ana-lyses indicated the competitive nature of theinteraction between Na+ and DS-201 on the enzymeof brain. The DS-201 inhibition was uncompetitive forATP, noncompetitive or mixed type in the presence ofK+ and Mg2+ for the brain enzyme. However, thereare some differences in the action of DS-201 on theheart microsomal Na+. K+-ATPase. |
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| Keywords: | sulfonic acids tanshinone sodium potassium adenosine triphosphatase heart brain microsomes |
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