皮肤血管瘤和血管畸形细胞增殖与凋亡的对比研究

目的：探讨皮肤血管瘤和血管畸形的细胞凋亡与增殖的平衡关系及与临床生物学行为的可能关系。方法：采用流式细胞术检测皮肤血管瘤和血管畸形组织中凋亡细胞比率及细胞周期分布,分析细胞凋亡/增殖水平。结果：血管瘤增生期和消退期凋亡/增殖水平出现下调和上调（P〈0.05）,而血管畸形细胞凋亡/增殖水平与正常皮肤相比无显著性差异（P〉0.05）。结论：细胞凋亡/增殖水平在皮肤血管瘤和血管畸形之间存在差异且可能与二者的病理演变过程密切相关。

Study on the relationship between the cell proliferation and apoptosis in skin hemangiomas and vascular malformations

Objective To evaluate the relationship between the cell apoptosis and proliferation in skin hemangiomas and vascular malformations and their correlation with the biological behaviors. Methods The apoptosis rates and cell cycle in skin hemangiomas and vascular malformations were detected by flow cytometer. Meanwhile, the ratio of apoptosis rates to proliferation index (AR/PI) was assessed and compared. Results AR/PI ratio was down-regulated in the proliferating phase of hemangiomas and was up-regulated in the involuting of hemangiomas(P<0.05). No significant difference of AR/PI ratio was found in vascular malformations and normal skin(P>0.05). Conclusion The relationship between the cell proliferation and apoptosis in skin hemangiomas was obviously different from that of vascular malformations, which might be involved in the progression of two diseases.