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Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract |
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| Authors: | Owoyele Victor B Wuraola Caleb O Soladoye Ayodele O Olaleye Samuel B |
| Affiliation: | a Department of Physiology and Biochemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria b Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria |
| Abstract: | A methanol extract of the dried leaves of Tithonia diversifolia was investigated for anti-inflammatory and analgesic activities. The extract (50–200 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55 °C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions. |
| Keywords: | Tithonia diversifolia (Hemsl) A. Gray Anti-inflammatory Analgesic Properties |
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