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Concurrent lithium administration results in higher haloperidol levels in brain and plasma of guinea pigs |
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| Authors: | Zita C. Nemes Jan Volavka Abel Lajtha Thomas B. Cooper Henry Sershen |
| Affiliation: | 1 are in the Department of Psychiatry, New York University School of Medicine, USA. 2 is in the Division of Clinical Research, Nathan S. Kline Institute for Psychiatric Research, USA 3 are also at the Manhattan Psychiatric Center, Ward's Island, NY, USA. 4 Mr. Cooper is also at the New York State Psychiatric Institute, USA. |
| Abstract: | The effects of lithium (Li) on brain and plasma levels of concurrently administered haloperidol (HAL) were investigated. One group of guinea pigs (n=12) was also treated with HAL for 11 days, but Li was added during the last 5 days of treatment. At the end of treatment, the HAL + Li group had significantly higher brain and plasma levels of HAL than the group treated with HAL alone. The correlation coefficient between plasma and brain HAL (0.97) indicated that plasma levels of HAL determine brain levels of this drug. |
| Keywords: | Lithium haloperidol brain plasma guinea pigs |
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