骨康胶囊合并非甾体抗炎药致肝损伤2例

目的　提醒临床医生联合用药时注意药物不良反应的叠加。方法　报道2例骨康胶囊合并非甾体类抗炎药后出现肝功能损伤的病例资料，查阅文献分析该药导致肝功能损伤的关联性和发病机制。结果　2例患者停用骨康胶囊及非甾体抗炎药物并给予保肝药物治疗后，肝功能均恢复正常。通过因果关系评估表评估得分均为7分，相关性判断为“很可能”。结论　患者使用骨康胶囊合并非甾体抗炎类药物时需加强肝功能监测，关注其肝损伤的不良反应。

Two cases of liver injury caused by Gukang capsules combined with non-steroidal anti-inflammatory drugs

Objective　To remind clinicians topay attention to the superposition of adverse drug reactions when usingcombination drugs. Methods　This paper reports the data of 2 cases of liver injury caused byGukang capsules combined with non-steroidal anti-inflammatory drugs. Literaturereview was conducted to analyze the correlation and pathogenesis of liverfunction injury caused by the drugs. Results　The liver function of the two patientsreturned to normal after withdrawal of Gukang capsules and non-steroidal drugsand treatment with hepatoprotective drugs. Both of them scored 7 points on thecausality assessment form, and the correlation was judged as very likely. Conclusion　It is necessary to strengthen liver function monitoring and payattention to the adverse reactions of liver injury when patients take Gukangcapsules and non-steroidal anti-inflammatory drugs.