新型冠状病毒肺炎患者血清白蛋白水平与患者病情的相关分析

目的:探讨新型冠状病毒肺炎（coronavirus disease 2019，COVID-19）患者血清白蛋白水平与患者病情的关系。方法:回顾性分析2020年1月23日至3月5日期间福建省福州肺科医院出院的70例COVID-19患者临床资料，按血清白蛋白水平将患者分为正常白蛋白组（43例）和低蛋白血症组（27例）。统计...

Correlation between serum albumin level and severity in COVID-19 patients

Objective　To investigate therelationship between serum albumin level and severity in patients withcoronavirus disease 2019 (COVID-19). Methods　The clinical data of 70 COVID-19 patients inFuzhou Pulmonary Hospital of Fujian Province from January 23, 2020 to March 5,2020 were analyzed retrospectively. According to the initial serum albuminlevel, the enrolled patients were divided into a normal albumin group (43cases) and a hypoalbuminemia group (27 cases). Then, the differences in bothgroups were analyzed about serum albumin levels and chest imaging scores on the1^st, 7^th, and 14^th day after admission, aswell as nucleic acid turning negative time. Independent sample t test was used to compare themeasurement data between groups, and χ² test or Fisher's exact probability method was used to compare the countdata between groups. Results　Among the 70 patients, 36 were male and 34 were female, aged(43.53±14.91) years. The patients in the hypoalbuminemia group were older (t=3.117, P=0.003) and had a higher incidence of underlying diseases (χ²=9.807, P=0.002) and cough (χ²=7.396, P=0.007)than those in the normal albumin group. The serum albumin levels in thehypoalbuminemia group were (39.66±3.77) g/L, (32.58±4.00) g/L, and (36.20±2.27)g/L on the 1^st, 7^th, and 14^th day afteradmission, which were lower than those in the normal albumin group[(43.55±5.67) g/L, (41.18±6.16) g/L, and (41.82±4.87) g/L], with statisticallysignificant differences (all P<0.05).The chest imaging scores in the hypoalbuminemia group were (6.88±2.80) points,(6.57±2.98) points, and (4.88±2.47) points on the 1^st, 7^th,and 14^th day after admission, which were higher than those in thenormal albumin group [(4.85±2.76) points, (4.58±3.21) points, and (3.45±1.74)points], with statistically significant differences (all P<0.05). The nucleic acid turning negative time in thehypoalbuminemia group was (22.68±4.60) d, longer than that in the normalalbumin group [(19.50±5.36) d], with a statistically significant difference (t=-2.329, P=0.023). Conclusions　The serum albumin level in COVID-19 patients is closely related tothe severity of patients' condition. The lower the serum albumin level inpatients, the more severe the chest image and the longer the nucleic acidturning negative time.