腰高比与超重2型糖尿病视网膜病变相关性研究

目的　探讨腰高比（WHtR）与超重2型糖尿病（T2DM）视网膜病变（DR）的相关性。方法　招募2019年11月至2020年8月在郑州大学附属洛阳中心医院内分泌科收治的符合条件的620例超重T2DM者，进行回顾性横断面研究，根据是否合并DR分为单纯超重T2DM组和超重T2DM合并DR组，并收集其一般资料及临床指标等，组间比较用t检验，计数资料组间比较用卡方检验；通过统计学分析WHtR与超重DR的相关性。结果　单纯超重T2DM组男282例，女137例，共419例，占总例数67.6%；超重T2DM合并DR组男104例，女97例，共201例，占总例数32.4%。与单纯超重T2DM组相比，超重T2DM合并DR组男性比例更高（P<0.001），相对更高的身高（P=0.001）、体质量指数（P=0.023），更大的腰围（P=0.001）、臀围（P=0.011）、WHtR（P<0.001），糖尿病病程相对更长（P<0.001），更高的糖化血红蛋白（P<0.001），高血压病的发生率更高（P<0.001）。将单因素中有意义的指标纳入多因素logistic分析模型中,结果提示：性别比值比（OR）：0.566，95%置信区间（CI）：0.331~0.969，P=0.038）、身高（OR：0.933，95%CI：0.913~0.952，P<0.001）、腰围（OR：1.163，95%CI：1.083~1.249，P<0.001）、WHtR（OR：1.074，95%CI：1.063~1.857，P=0.007）、糖尿病病程（OR：1.056；95%CI：1.027~1.087，P<0.001）、糖化血红蛋白（OR：1.560，95%CI：1.391~1.749，P<0.001）、高血压病（OR：1.478，95%CI：1.323~1.707，P<0.001）可能是超重DR的相关危险因素。结论　WHtR与超重DR具有相关性。

Correlation between waist-to-height ratio and diabetic retinopathy in over-weight patients with type 2 diabetes mellitus

Objective　To assess the correlation between waist-to-height ratio (WHtR) and diabetic retinopathy (DR) in over-weight patients with type 2 diabetes mellitus (T2DM). Methods　A total of 620 over-weight patients with T2DM treated at Department of Endocrinology, Luoyang Central Hospital Affiliated to Zhengzhou University from November 2019 August 2020 were included for a retrospective cross-sectional study. According to whether they were complicated with DR, the patients were divided into an over-weight T2DM group and an over-weight T2DM combined with DR group. Their general data and clinical indicators were collected. The t test was used for the comparison between the two groups, and the chi-square test was used for the comparison of count data between the two groups. The correlation between WHtR and DR in the over-weight patients with T2DM were statistically analyzed. Results　There were 419 cases (67.6%) in the over-weight T2DM group, including 282 males and 137 females; there were 201 cases (32.4%) in the over-weight T2DM combined with DR group, including 104 males and 97 females. Compared with the over-weight T2DM group, the over-weight T2DM combined with DR group had a higher proportion of men (P<0.001), relatively higher height (P=0.001), higher body mass index (BMI) (P=0.023), larger waist circumference (P=0.001), larger hip circumference (P=0.011), higher WHtR (P<0.001), relatively longer duration of T2DM (P<0.001), higher HbA1c (P<0.001), and a higher incidence of hypertension (P<0.001). The multivariate logistic regression analysis showed that gender (OR=0.566, 95%CI 0.331-0.969, P=0.038), height (OR=0.933,95%CI 0.913-0.952, P<0.001), waist circumference (OR=1.163, 95%CI 1.083-1.249, P<0.001), WHtR (OR=1.074, 95%CI 1.063-1.857, P=0.007), T2DM course (OR=1.056, 95%CI 1.027-1.087, P<0.001), HbA1c (OR=1.560, 95%CI 1.391-1.749, P<0.001), hypertension (OR=1.478, 95%CI 1.323-1.707, P<0.001) might be the associated risk factors with DR in the over-weight patients with T2DM. Conclusion　WHtR is associated with DR in over-weight patients with T2DM.