UGT1A1基因多态性对宝安地区女性妊娠期甲状腺功能减退的临床价值

目的:探究尿苷二磷酸葡萄糖醛酸转移酶1A1（UGT1A1）基因多态性对宝安地区女性妊娠期甲状腺功能减退的临床价值。方法:以2021年1月至2022年2月就诊于深圳市宝安区石岩人民医院妊娠期甲状腺功能减退的女性100例为观察组，同时选取同期产检甲状腺功能正常的健康女性100例为对照组。取所有研究对象的空腹静脉血，进行RN...

Clinical value of UGT1A1 gene polymorphism in women with hypothyroidism during pregnancy in Bao'an area

Objective　To explore the clinicalvalue of uridine 5′-diphospho-glucuronosyltransferase 1-1 (UGT1A1) genepolymorphism in pregnant women with hypothyroidism in Bao'an area. Methods　Onehundred women with hypothyroidism during pregnancy treated at Shiyan People'sHospital from January 2021 to February 2022 were selected as an observationgroup, and 100 healthy women with normal thyroid function taking propertyinspection during the same period were selected as a control group. The fastingvenous blood of all the subjects was taken for RNA extraction and sequencing.The observation group were routinely treated with levothyroxine tablets for 4weeks. The serum levels of thyroid stimulating hormone (TSH) and thyroidperoxidase antibody (TPOAb) were detected. The χ², paired t,or F tests were applied. Results　Inthe observation group, there were 73 cases of UGT1A1*6 wild type, 23 cases ofheterozygous mutation type (G/A), 4 cases of homozygous mutation type (A/A), 70cases of UGT1A1*28 wild type, 27 cases of G/A type, and 3 cases of A/A type; inthe control group, there were 69 cases of UGT1A1*6 wild type, 26 cases of G/A type,5 cases of A/A type, 72 cases of UGT1A1*28 wild type, 26 cases of G/A type, and2 cases of A/A type; there were no statistical differences in UGT1A1*6 andUGT1A1*28 gene polymorphisms between the observation group and the controlgroup (both P>0.05). Before thetreatment, there were no statistical differences in TSH and TPOAb levelsbetween the patients with different UGT1A1*6 and UGT1A1*28 genotypes (all P>0.05); after the treatment, the TSHand TPOAb levels of the patients of UGT1A1*6 and UGT1A1*28 wild types were thehighest, those of the patients of UGT1A1*6 G/A type were the second, and theTSH level of the patients of UGT1A1*6 A/A type was the lowest, with statisticaldifferences (all P<0.05). Conclusions　The UGT1A1 gene polymorphism in women with hypothyroidism duringpregnancy is similar to that in healthy pregnant women. The levels of TSH andTPOAb in patients with UGT1A1*6 and UGT1A1*28 homozygous mutant hypothyroidismsduring pregnancy after clinical treatment are significantly reduced. Clinically,it should consider to give an appropriate dose of drug treatment according tothe UGT1A1 genotypes.