持续48 h静脉灌注5-FU联合顺铂治疗鼻咽癌观察

目的探讨5-Fu持续48h静脉灌注联合顺铂治疗晚期鼻咽癌的近期疗效和不良反应。方法全组瘸例采用甲酰四氢叶酸钙（CF）200mg／m^2静滴，5-FU 0．5g于CF滴至一半时静脉推注，接着5-FU 3．0g／m^2持续静脉灌注48h，在整个5-FU灌注过程中每6小时口服安曲希片75mg，共7次，每例患者均联合使用顺铂30mg连用5d，所有患者均接受4个疗程以上的化疗。结果CR2例，PR15例，NC18例，PD17例。总有效率为32．69％。主要不良反应为外周静脉炎、口腔黏膜炎、腹泻、恶心和呕吐、骨髓抑制和脱发等。结论5-FU持续48h静脉灌注联合顺铂治疗晚期鼻咽癌的近期疗效优越，且不良反应轻。

Clinical study on cisplatin and 48 hours continuous infusion 5-FU combination chemotherapy for advanced nasopharyngel carinoma

Objective To evaluate the short-term efficacy and toxicity of cisplatin combined with 48 hours continuous infusion 5-FU on the treatment of advanced nasopharyngel carinoma.Methods In all cases,CF 200mg/m~2 pluse 5-FU 0.5g was injected,and after that,5-FU 4.5g was infused in 48 hours.Antrets 75mg(15mg/tablet) were fed every 6 hours by 7 times during the infusion.Cisplatin 30mg was used from 1rd day to 5th day.All cases received no less than 4 courses treatment.Results It showed that CR 2,PR 15,NC 18,PD 17 cases with an overall effective rate of 32.69%.The main side effects included peripheral hlebitis,mucositis,mucositis,diarrhoea,nausea and vomiting,neutropenia,alopecia and so on.Conclusion Cisplatin combined with 48 hours continuous infusion 5-FU on the treatment of advanced nasopharyngel carinoma is efficient and the toxicity is able to tolerable,which can be practiced safely.