| 不同乳化剂制备阿司匹林微球工艺的研究 |
| |
| 引用本文： | 冼远芳,程凤梅,于宝洁. 不同乳化剂制备阿司匹林微球工艺的研究[J]. 西北药学杂志, 2007, 22(5): 259-260 |
| |
| 作者姓名： | 冼远芳 程凤梅 于宝洁 |
| |
| 作者单位： | 1. 长春工业大学化工学院制药工程系,吉林,长春,130123
2. 长春工业大学生物工程学院,吉林,长春,130122 |
| |
| 摘 要： | 目的以聚乳酸为载体用溶剂挥发法制得阿司匹林聚乳酸微球。方法选择不同的乳化剂,正交设计实验。以微球包埋率、载药量、表面形态、体外释放为指标优化微球的制备工艺。结果与结论按优化条件制得的微球粒径5～22μm,占80%以上。微球包埋率39.5%,载药量7.25%,体外释药50%需70h。
|
| 关 键 词： | 阿司匹林 聚乳酸 乳化挥发法 正交实验 缓释微球 |
| 文章编号： | 1004-2407（2007）05-0259-02 |
| 收稿时间： | 2006-11-25 |
| 修稿时间： | 2006-11-25 |
Preparation of polylactic acid enveloped aspirin microspheres |
| |
| XIAN Yuan-fang,CHENG Feng-mei,YU Bao-jie. Preparation of polylactic acid enveloped aspirin microspheres[J]. Northwest Pharmaceutical Journal, 2007, 22(5): 259-260 |
| |
| Authors: | XIAN Yuan-fang CHENG Feng-mei YU Bao-jie |
| |
| Affiliation: | School of Chemical Engineering, Changchun University of Technology, Changchun J ilin 130012, China; School of Bological Engineering, Changchun University of Technology, Chang chun J ilin 130012, China |
| |
| Abstract: | Objective Polylactic acid enveloped aspirin microspheres were prepared by solvent evaporation method.Method The orthogonal test of 3 factors and 3 levels was applied to optimize the preparation procedure.The particle appearance,drug content,and rate of encapsulation were used to evaluate the preparation procedure.Results and Conclusion Microspheres in the range of 5~22 μm were obtained.The drug content was 7.25% and encap sulated rate was 39.5%,and t1/2(in vitro) was 70 h.The results showed the microspheres prepared dy the method had obviously release effect. |
| |
| Keywords: | aspirin polylactic acid emulsion-solvent evaporation method orthogonal tast release microspheres |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
