| 钆标记抗人肺癌单抗的磁共振免疫成像研究 |
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| 引用本文： | 许乙凯,刘杏元,朱正兵,黄其鎏,颜江华,俞志坚.钆标记抗人肺癌单抗的磁共振免疫成像研究[J].现代医用影像学,1999(4). |
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| 作者姓名： | 许乙凯 刘杏元 朱正兵 黄其鎏 颜江华 俞志坚 |
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| 作者单位： | 广州第一军医大学南方医院影像中心!510515(许乙凯，刘杏元，朱正兵，黄其鎏)，厦门大学抗癌研究中心(颜江华)，珠江医院(俞志坚) |
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| 摘 要： | 目的：探讨Gd标记抗肺癌单抚对荷瘤裸鼠的定向增强效应。材料与方法：用DTPA环二酸研与抗肺癌单抗3D3和Gd3~3 分别偶联，制备出Gd－DTPA－IgG：建立6只荷瘤裸鼠模型；将Gd－DTPA－IgG按2mg单抗／只的剂量从尾静脉内注入；观察平扫及注药后6小时瘤体磁共振信号。结果：Gd－DTPA－IgG能选择性增加瘤灶的信号强度。结论：磁共振免疫成像为肺癌定性提供一种潜在新的方法。
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| 关 键 词： | 肺肿瘤 单克隆抗体 磁共振成像 |
MR Immunoimaging Using Antihuman Lung Cancer Monoclonal Antibodies Labelled Gadolinium |
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| Xu Yikai, Yu Zhijian, Yan Jianghua et,al..MR Immunoimaging Using Antihuman Lung Cancer Monoclonal Antibodies Labelled Gadolinium[J].Modern Medical Imagelogy,1999(4). |
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| Authors: | Xu Yikai Yu Zhijian Yan Jianghua et al |
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| Abstract: | Purpose: To explore the Possibilitv of specific contrast enhancemen1 in nude mice hosted lung cancer using Gd labelled monocloa1 antibodies against lung adenocarcinorna. Materials and Methods: Uslng cyclic anhydride DTPA as a bifunctional chelat1ng a- gent, Gd3 was attached to a monoclnal antihody (3D3). 6 nude mlce carrying the 1ung cancer were esta)lished. Then, Gd - DTPA - IgG was intravenously injected at a dose of 2mg IgG/mouse. MR scans wcre performed before and 6 hours after administration of Gd - DTPA - IgG. ResultS: all tumor of nodules were specifically cnhancecl with Gd - DTPA - IgG. ConcIusion: MR immunoimaging is a promise method for detecting lung cancer. |
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| Keywords: | Lung neoplasms Monocloal Antobodies Magnetic Resonance Imaging |
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