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Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis
Authors:Marion J. Pollheimer  Silvia Racedo  Amanda Mikels-Vigdal  Derek Marshall  Christopher Bowlus  Carolin Lackner  Tobias Madl  Tom H. Karlsen  Johannes R. Hov  Susan K. Lyman  Joanne Adamkewicz  Victoria Smith  Emmanuel Moreau  Gernot Zollner  Tor Jacob Eide  Tatjana Stojakovic  Hubert Scharnagl  Hans-Jürgen Gruber  Peter Fickert
Affiliation:1. Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria;2. Institute of Pathology, Medical University of Graz, Austria;3. Gilead Sciences, Foster City, CA, USA;4. Division of Gastroenterology and Hepatology, University of California Davis School of Medicine Davis, CA, USA;5. Institute of Molecular Biology and Biochemistry, Medical University of Graz, Austria;6. Norwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and Institute of Clinical Medicine, University of Oslo, Norway;7. BioMérieux SA, Marcy l’Etoile, France;8. Department of Internal Medicine, Medical University of Graz, Austria;9. Department of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway;10. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria;11. Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria
Abstract:
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  • Keywords:Cholangiopathy  Epithelial barrier function  Liver fibrosis  Lysyl oxidases  Primary sclerosing cholangitis  Tight junction
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