| LOSS OF HETEROZYGOSITY ON CHROMOSOME 17p13.3 IN OVARIAN CANCER AND CERVICAL CANCER |
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| 作者姓名： | 张国玲 杨慧娟 许凯黎 周瑾 秦瑞娣 陆明华 |
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| 作者单位： | Zhang Guoling 1 Yang Huijian 1 Xu Kaili 2 Zhou Jin 2 Qin Ruidi 1 Lu Minghua 2 1 Department of Gynecology，Shanghai Cancer Hospital，Shanghai Medical University，Shanghai 200032 2 Shanghai Cancer Institute，Shanghai 200032 |
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| 摘 要： | ＣａｒｃｉｎｏｇｅｎｅｓｉｓｃｏｎｓｉｓｔｓｏｆｍｕｌｔｉｐｌｅｑｕａｌｉｔａｔｉｖｅｌｙｄｉｆｆｅｒｅｎｔｓｔｅｐｓｉｎｗｈｉｃｈａｃｃｕｍｍｕｌａｔｉｏｎｏｆＤＮＡａｌｔｅｒａｔｉｏｎｏｃｕｒｓａｎｄｃｒｉｔｉｃａｌｅｖｅｎｔｓ，ｉｎｖｏｌｖｉ...
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Loss of heterozygosity on chromosome 17p13.3 in ovarian cancer and cervical cancer |
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| Guoling Zhang,Huijian Yang,Kaili Xu,Jin Zhou,Ruidi Qin,Minghua Lu.LOSS OF HETEROZYGOSITY ON CHROMOSOME 17p13.3 IN OVARIAN CANCER AND CERVICAL CANCER[J].Chinese Journal of Cancer Research,1998,10(4):260-263. |
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| Authors: | Guoling Zhang Huijian Yang Kaili Xu Jin Zhou Ruidi Qin Minghua Lu |
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| Institution: | (1) Department of Gynecology, Shanghai Cancer Hospital, Shanghai Medical University, 200032 Shanghai;(2) Shanghai Cancer Institute, 200032 Shanghai |
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| Abstract: | Objective: To identify the loss of heterozygosity (LOH) on chromosome 17p13 3 in ovarian cancer and cervical cancer Methods: The frequency of LOH on chromosome 17p13 3 in DNA samples from 24 ovarian cancers, 9 cervical cancers, and 13 non malignant gynecological diseases were determined respectively, using Southern blot method with probe PYNZ 22 Results: LOH on 17p13 3 was found in 12 of 24 (50 0%) ovarian cancers (including a borderline mucinous cystadenoma), 4 of 9 (44 4%) cervical carcinomas, and 1 of 13 (7 7%) non malignant gynecological diseases, which was cervical intraepithelial neoplasm III (CIN III) ( P< 0 01) Conclusion: These results show that LOH on 17p13 3 is associated with ovarian cancer and cervical cancer, suggesting that detection of LOH on 17p13 3 may be helpful to understand the molecular pathogenesis of ovarian cancer and cervical cancer |
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| Keywords: | Ovarian neoplasms Cervical neoplasms 17p13 3 LOH |
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