黄杆菌致下呼吸道感染的危险因素和耐药性分析

目的：探讨黄杆菌致下呼吸道感染的危险因素及其耐药性的分布情况。方法：分析26例黄杆菌致下呼吸道感染的临床资料，采用平板稀释法测定常用抗菌药物对该株菌的最低抑菌浓度（MIC）。结果：26例中＞60岁者15例（58％），全部病例均有基础疾病，其中以恶性肿瘤最常见（31％），50％病例为混合感染，发病的危险因素为：广谱抗菌药物的应用（81％）；机体的免疫抑制（77％）；侵袭性治疗（31％）；长期住院，临床症状及X线表现无特异性。耐药率高，众多常用药物中，仅有环丙沙星，复方磺胺甲恶唑（复方新诺明）及哌拉西林耐药率低于40％，结论：黄杆菌致下呼吸道感染多发生于患有各种基础疾病，免疫功能低下及长期应用广谱抗菌药物者，临床表现无特异性，细菌的耐药现象严重，诊断及治疗有赖于病原学检查。

Analysis of the risk factors and drug resistance of lower respiratory tract infection by Flavobacteria

Objective To investigate risk factors of 26 cases with lower respiratory tract infection caused by Flavobacteria and its antimicrobial susceptibility in vitro . Methods Retrospective study of the clinical materials of 26 cases of lower respiratory tract infection caused by Flavobacteria Antimicrobial susceptibility (MIC) was determined with the method of agar dilution. Results All of 26 cases suffered from underlying diseases,among them malignant tumors were most common(31%) illness 50% of the cases were mixed infections Risk factors of infections were application of multiple antibiotics(81%),host immune suppression (77%),invasive manasements (31%),and prolonged hospitalization No specific clinical manifestations and chest X ray appearance revealed Isolates were highly resistant to most of antimicrobial agents. Ciprofloxacin,trimethoprim sulfamethoxazole and piperacillin are the most sensitive agents Conclusions Lower respiratory tract infection caused by Flavobacteria developed most commonly in patients who suffered from various underlying diseases,immunodeficiency,and longtime antibiotic overuse. Clinical isolates were highly resistant to most kinds of antimicrobial agents