新生化冲剂的主要药效学研究

目的研究新生化冲剂的主要药效作用.方法采用灌胃给药,以生理盐水作为阴性对照组,生化汤丸作为阳性对照组,观察新生化冲剂高剂量、中剂量、低剂量对雌激素引起的小鼠子宫增重的作用、对醋酸引起扭体反应的作用及对小鼠单核吞噬细胞吞噬功能的影响.结果新生化冲剂高,中剂量与生理盐水组比较具有显著抑制己烯雌酚促进性成熟小鼠子宫增重作用(P＜0.01)、提高小鼠单核吞噬细胞吞噬功能(P＜0.01),新生化冲剂高剂量与生理盐水组比较具有抑制醋酸引起扭体反应的次数(P＜0.05).结论新生化冲剂能抑制己烯雌酚增重子宫的作用,并具有镇痛及提高机体免疫功能的作用.

The Main Pharmacological Effects of Xinshenhua Granule

Objective:The main Pharmacological effects of Xinshenhua Granule were investigated.Methods:The drugs were given by mouth.The negative control group and the positive control group were saline solution and shenghuatang pill respectively.The influences of the weights of uterus of mice induced by estrogen,writhing test induced by acetic acid and the function of mononuclear cells of mice were observed at three different doses of Xinshenhua granule.Results:The high dose and middle dose of Xinshenhua granule can markedly inhibit the weights of uterus of sex mature mice induced by diethylstilbestrol(P<0.01),and can raised the phagocytic function of mice mononuclear cell(P<0.01).The high dose of Xinshenhua granule canmarkedly inhibit the number of writhing reaction compared with normal saline group(P<0.05).Conclusion:Xinshehua granule can inhibit the weights of uterus induced by diethylstilbestrol,has analgetic effect and can raise the immunity function.