Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span |
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| Authors: | Mitsui Akira Hamuro Junji Nakamura Hajime Kondo Norihiko Hirabayashi Yoko Ishizaki-Koizumi Sonoko Hirakawa Tadashi Inoue Tohru Yodoi Junji |
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| Institution: | Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, 210-8681, Japan. |
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| Abstract: | Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of the protein in a variety of stresses. Bone marrow cells from TRX-Tg mice were more resistant to ultraviolet C-induced cytocide compared with those from wild type (WT) C57BL/6 mice. TRX-Tg mice exhibited extended median and maximum life spans compared with WT mice. Telomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice. These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals. |
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