LVEF保留的老年重度心力衰竭患者NT-proBNP与年龄的相关性

目的：探讨左室射血分数（LVEF）保留的老年重度心力衰竭患者的血氨基末端脑钠肽前体（NT-proBNP）与年龄的关系。方法450例住院的老年重度心力衰竭（NYHAⅢ-Ⅳ级）患者根据LVEF情况不同分为两组,即LVEF≥50%（LVEF保留）组和LVEF〈50%（LVEF降低）组。比较两组患者的临床资料,进行对照分析。同时对血NT-proBNP对数值 Log （NT-proBNP）与年龄进行线性相关分析。结果 LVEF保留组老年重度心力衰竭患者183例,LVEF降低组老年重度心力衰竭患者267例。LVEF保留组老年重度心力衰竭患者的LVEDD及Log（NT-proBNP）值均低于LVEF降低组（P〈0.01）。LVEF保留组老年重度心力衰竭患者的Log（NT-proBNP）值与年龄呈正相关（r=0.207,P〈0.01）。结论血浆NT-proBNP对LVEF保留的老年重度心力衰竭患者的诊断价值远不如对LVEF降低的老年重度心力衰竭患者；但其血浆NT-proBNP水平随着年龄的增加而升高。

The correlation of NT-proBNP and age in LVEF reserved elderly patients with severe heart failure

Objective To explore the relationship of plasma NT-proBNP and age in elderly patients with severe heart failure with left ventricular ejection fraction （LVEF） preserved. Methods According to LVEF, 450 inpatients with severe heart failure （NYHA III-Ⅳ） were divided into two groups.They were LVEF≥50%（LVEF preserved） group and LVEF〈50%（LVEF decreased） group. Clinical data were compared and analysed between the two groups. Linear correlation analysis was applied between Log （NT-proBNP） values of patients and ages. Results LVEF preserved group of elderly patients with severe heart failure were 183 cases. LVEF decreased group of elderly patients with severe heart failure were 267 patients. LVEDD and Log（NT-proBNP） values in LVEF preserved group of elderly patients with severe heart failure were lower than that in LVEF decreased group（P〈0.01）. Log（NT-proBNP） values of LVEF preserved group of elderly patients with severe heart failure were positively correlated with ages （r=0.207, P〈0.01）. Conclusion Diagnostic value of plasma NT-proBNP on LVEF preserved patients in elderly with severe heart failure was far inferior to LVEF decreased patients in elderly with severe heart failure. The level of plasma NT-proBNP increased with age.