2型糖尿病合并急性脑梗死患者血糖波动与颈动脉内膜厚度的相关性分析

目的：探讨T2DM合并急性脑梗死患者血糖波动与IMT的关系。方法收集2013年1月~2014年2月我院住院的T2DM患者45例将其作为T2DM组,收集与T2DM组患者相同时间段来我院住院治疗的T2DM合并急性脑梗死患者50例将其作为DMCI组,测定两组患者颈动脉IMT,将DMCI组分为IMT增厚组29例、IMT正常组21例,比较各组资料并对IMT与其他指标的相关性进行分析。结果①DMCI组SBP、DBP、LDL-C、TC、TG、HbA1C、IMT、MAGE均显著高于T2DM组,两组差异有统计学意义（P〈0.05）。②IMT增厚组SBP、LDL-C、IMT、MAGE均显著高于IMT正常组,两组差异有统计学意义（P〈0.05）。③MAGE、LDL-C、SBP为IMT的影响因素（P〈0.05）。结论对高血糖患者高效平稳降糖降低血糖波动幅度能使动脉硬化风险降低,减少糖尿病并发症的发生。

Analysis on the relationship of type 2 diabetes patients with acute glucose fluctuations and carotid artery intima-media thickness of cerebral infarc-tion

Objective To investigate the relationship of T2DM with acute glucose fluctuations and IMT. Methods Forty-five cases of T2DM patients were selected from January 2013 to 2014 February in our hospital as T2DM group, 50 cases of T2DM patients with acute cerebral infarction were selected in our hospital on the same period with T2DM group as DMCI group,the carotid artery IMT of two groups were measured, the patients in the DMCI group were divided into IMT thickening group（n=29）, IMT normal group（n=21）, the data of every groups were compared and the correlation of IMT with other indicators were analyzed. Results ①SBP, DBP, LDL-C, TC, TG, HbA1C, IMT, MAGE of DMCI group were higher than T2DM group, the difference was significant（P〈0.05）. ②SBP, LDL-C, IMT, MAGE IMT of IMT thickening group was significantly higher than IMT normal group, the difference was significant （P 〈0.05）. ③MAGE, LDL-C, SBP were the influence factors for IMT （P〈0.05）. Conclusion Patients with high blood sugar stable and effi-cient glucose lowering blood sugar fluctuations can reduce the risk of atherosclerosis, reduce the incidence of diabetic complications.