拉坦前列素、曲伏前列素和噻吗洛尔治疗原发性开角型青光眼的疗效比较分析

目的：比较拉坦前列素、曲伏前列素及噻吗洛尔滴眼液治疗原发性开角型青光眼（ POAG）的效果。方法将收治的120例患者随机分为A、B、C组，每组均为40例，其中A 组患者给予拉坦前列素滴眼液；B组患者给予曲伏前列素滴眼液；C组患者给予马来酸噻吗洛尔滴眼液，A、B组均为每天晚上约20：00给药1次，每次1滴，疗程为4周，C组为每天早上约08：00给药1次，每次1滴，疗程为4周。结果三组患者治疗前比较，眼压无统计学差异（ P ＞0．05），三组患者用药治疗4周眼压值均有显著下降，用药前后差异具有统计学意义（ P ＜0．05）；拉坦前列素和曲伏前列素两种滴眼液组间治疗无显著性差异（ P ＞0．05），但与噻吗洛尔治疗分别进行组间效果比对具有显著性差异（ P ＜0．05）。结论拉坦前列素、曲伏前列素及噻吗洛尔滴眼液治疗POAG在一个疗程内（4周）均能有效降低眼压，疗效持久，且两种前列素降眼压作用明显优于噻吗洛尔滴眼液治疗效果。

Effects comparison of latanoprost,travoprost and timolol in the treatment of primary open angle glaucoma

Objectives To compare the effect of latanoprost, travoprost and timolol in primary open angle glauco-ma ( POAG) patients.Methods 120 patients with POAG were randomly divided into 3 groups, with 40 cases in each group.Group A, group B and group C were treated once daily with latanoprost, travoprost and timolol eyedrops respective-ly, and a drop was given at 8 PM every night for every time in four weeks.Results There was no difference of intraocular pressure (IOP) before the treatment among the three groups ( P >0.05), but IOP became lower among the three groups 4 weeks after the treatment, the differences were statistically significant ( P <0.05).The mean IOP reducation were signifi-cantly differernt among the groups, specifically, the latanoprost group and travoprost group in comparison to the timolol group at week 4 ( P <0.05) .Conclusions Latanoprost, travoprost and timolol eyedrops are all effective and hosting in reducing IOP in POAG, but the curative effect of latanoprost and travoprost eyedrops are better than timolol eyedrops.