RECOVERY OF LUTEAL FUNCTION AFTER INTERRUPTION OF GONADOTROPHIN SECRETION IN THE MID-LUTEAL PHASE OF THE MENSTRUAL CYCLE |
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| Authors: | D. W. POLSON M. SAGLE H. D. MASON D. KIDDY S. FRANKS |
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| Affiliation: | Department of Obstetrics and Gynaecology, St Mary's Hospital Medical School, London. |
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| Abstract: | Ovulation was induced by a pulsatile infusion of GnRH in a patient with hypogonadotrophic amenorrhoea. In order to investigate the effect of short-term withdrawal of gonadotrophin support in the luteal phase, the pulsatile infusion was stopped 3 d after ovulation and restarted 48 h later. After stopping the pump gonadotrophin and progesterone concentrations fell rapidly to very low levels, but when the infusion was restarted progesterone concentrations returned to normal mid-luteal values. Menstruation occurred 14 d after the LH surge. We conclude that normal progesterone secretion by the corpus luteum can be restored after temporary withdrawal of gonadotrophin support. |
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