| 多发性肌炎和皮肌炎的肾脏损害分析 |
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| 引用本文： | 钱莹,任红,陈晓农,张文,李晓,史浩,陈楠. 多发性肌炎和皮肌炎的肾脏损害分析[J]. 上海交通大学学报(医学版), 2011, 0(4): 451-454 |
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| 作者姓名： | 钱莹 任红 陈晓农 张文 李晓 史浩 陈楠 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院肾脏科; |
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| 基金项目： | 上海市科委科研计划项目(08dz1900502); 上海市科委重点项目(07JC14037)~~ |
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| 摘 要： | 目的探讨多发性肌炎与皮肌炎合并肾脏损害的临床特点。方法收集2003年1月—2008年12月确诊为多发性肌炎和皮肌炎患者的临床资料,回顾性分析肾脏损害的发生率、损害程度和临床预后。结果在确诊的146例多发性肌炎和皮肌炎患者中,107例(73.29%)首诊于皮肤科,仅4例(2.74%)首诊于肾脏科;共30例患者出现不同程度的肾脏损害,发生率为20.5%。肾脏损害表现为单纯血尿者10例(33.33%),单纯蛋白尿6例(20.00%),蛋白尿合并血尿13例(43.33%),高血压7例(23.33%),水肿3例。10例单纯血尿患者中,镜下血尿>+++者7例;11例接受24 h尿蛋白定量检测患者中,尿蛋白<1 g/d者7例;4例首诊于肾脏科的患者均接受肾穿刺活组织检查,发现局灶节段性肾小球硬化2例,肾小球轻微病变和狼疮性肾炎各1例。所有患者均给予免疫抑制剂治疗。痊愈1例,病情好转或无恶化23例,治疗有效率为80.00%;5例患者死亡(4例并发多脏器功能衰竭,1例合并肺癌),病死率16.67%。结论多发性肌炎和皮肌炎患者发生肾脏损害并非罕见,临床表现为较明显的镜下血尿、少量蛋白尿和轻、中度高血压以及轻度肾功能异常;患者对免...
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| 关 键 词： | 多发性肌炎 皮肌炎 慢性肾脏病 |
Renal injury in patients with polymyositis and dermatomyositis |
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| QIAN Ying,REN Hong,CHEN Xiao-nong,ZHANG Wen,LI Xiao,SHI Hao,CHEN Nan. Renal injury in patients with polymyositis and dermatomyositis[J]. Journal of Shanghai Jiaotong University:Medical Science, 2011, 0(4): 451-454 |
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| Authors: | QIAN Ying REN Hong CHEN Xiao-nong ZHANG Wen LI Xiao SHI Hao CHEN Nan |
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| Affiliation: | QIAN Ying,REN Hong,CHEN Xiao-nong,ZHANG Wen,LI Xiao,SHI Hao,CHEN Nan(Department of Nephrology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai200025,China) |
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| Abstract: | Objective To investigate the clinical features of renal involvement in patients with polymyositis and dermatomyositis. Methods The clinical data of patients with polymyositis and dermatomyositis confirmed from January 2003 to December 2008 were collected,and the incidence,severity and prognosis of renal injury were retrospectively analysed. Results Of the 146 patients confirmed with polymyositis and dermatomyositis,107(73.29%) visited Department of Dermatology first,while only 4(2.74%) visited Department of... |
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| Keywords: | polymyositis dermatomyositis chronic kidney disease |
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