| 异黄酮化合物1461扩血管作用的探讨 |
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| 引用本文： | 赵忆琴,邵以德.异黄酮化合物1461扩血管作用的探讨[J].中国药理学通报,1985(1). |
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| 作者姓名： | 赵忆琴 邵以德 |
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| 作者单位： | 武汉冶金医专
(赵忆琴)，上海第一医学院药学系药理教研室(邵以德) |
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| 摘 要： | 本文通过离体兔主动脉条实验,证明1461对血管平滑肌有明显的松弛作用。其作用能被心得安减弱。又能使NA效应曲线右移,同样浓度10~(-5)M酚妥拉明、戊脉安及1461,它们的ID_(50)(即50％抑制量)分别为<4.5、5.6及6.58。1461与戊脉安对高K~+去极化所致的收缩有明显的抑制作用,1461(1.6×10~(-3)M与戊脉安(1.6×10~(-4)M)对KC1的阻遏率分别为43.7％及95.1％。在无Ca~(2+)溶液中,1461与戊脉安都能明显对抗外Ca~(2+)的收缩作用,又能使KC1最大反应率明显下降。据此,我们初步认为1461对血管平滑肌的松弛作用与戊脉安相似,但作用较弱。
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| 关 键 词： | 1461 戊脉安 心得安 去甲肾上腺素 酚妥拉明 高K~+ 兔主动脉条 |
Studies of the Vascular Relaxing Effect of Isoflavoid Compound 1461 |
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| Zhao Yiqing et al.Studies of the Vascular Relaxing Effect of Isoflavoid Compound 1461[J].Chinese Pharmacological Bulletin,1985(1). |
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| Authors: | Zhao Yiqing |
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| Institution: | Zhao Yiqing et al |
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| Abstract: | The effects of Isoflavoid compound 1461 on rabbit isolated aortic strips were studied. Like Isoprehaline, 1461 relaxed the vascular smooth muscle markedly, and the relaxation was depressed by Pro-pranolol. 1461 and Verapamil Significantly inhibited the contraction induced by extracellular Ca2 and intracelluar Ca2 .
It is probable that 1461 and Verapamil primarily inhibited the potential dependent Ca2 channel (PDC), prevented the influx of extracellular Ca2 and the release of intracellular Ca2 ; therefore 1461 is simillar to the calcium antagonist Verapamil, but the effect of 1461 is weaker than Verapamil. |
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| Keywords: | Isoflavoid (1461) Rabbit aortic strips Verapamil Phentolamine |
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