| 己酮可可碱对重症急性胰腺炎大鼠肺损伤的保护作用 |
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| 引用本文： | 王烜,邓明明,夏国栋,康敏. 己酮可可碱对重症急性胰腺炎大鼠肺损伤的保护作用[J]. 重庆医学, 2009, 38(24) |
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| 作者姓名： | 王烜 邓明明 夏国栋 康敏 |
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| 作者单位： | 四川省泸州医学院附属医院消化内科,646000;四川省泸州医学院附属医院消化内科,646000;四川省泸州医学院附属医院消化内科,646000;四川省泸州医学院附属医院消化内科,646000 |
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| 摘 要： | 目的 观察己酮可可碱对重症急性胰腺炎(SAP)大鼠相关肺损伤的保护作用,并探讨其可能的发病机制.方法 36只雌性SD大鼠随机分为假手术组、模型组、治疗组.采用5%牛磺胆酸钠逆行胰胆管注射的方法,复制大鼠SAP相关肺损伤模型.治疗组在模型制作前30min给予己酮可可碱.12h后分别对胰腺损伤、肺损伤程度进行病理评分,测定肺系数、胰腺湿重、血清淀粉酶,用ELISA法检测血清和支气管肺泡灌洗液中TNF-α、IL-6、IL-1β含量,用半定量RT-PCR法检测肺组织中NF-κB p65 mRNA的表达.结果与模型组比较,治疗组胰腺及肺损伤程度明显减轻;其血清和支气管肺泡灌洗液中TNF-α、IL-6、IL-1β含量明显下降,肺组织中NF-κB p65 mRNA的表达亦明显减少.结论己酮可可碱对SAP相关急性肺损伤具有保护作用,其机制可能与抑制肺组织中NF-κB p65 mRNA的表达,从而抑制促炎细胞因子TNF-α、IL-6、IL-1β的产生相关.
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| 关 键 词： | 胰腺炎 肺损伤 己酮可可碱 细胞因子 |
Protective effect of pentoxifylline on severe acute pancreatitis associated lung injury in rats |
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| WANG Xuan,DENG Ming-ming,XIA Guo-dong,et al.. Protective effect of pentoxifylline on severe acute pancreatitis associated lung injury in rats[J]. Chongqing Medical Journal, 2009, 38(24) |
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| Authors: | WANG Xuan DENG Ming-ming XIA Guo-dong et al. |
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| Affiliation: | WANG Xuan,DENG Ming-ming,XIA Guo-dong,et al.(Department of Gastroenterology,Affiliated Hospital of Luzhou Medical College,Luzhou,Sichuan 646000,China) |
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| Abstract: | Objective To investigate the protective effect and possible mechanism of pentoxifylline on severe acute pancreatitis associated lung injury in rats.Methods Thirty-six female Sprague-Dawley(SD) rats were divided into sham operated group,model group and treatment group.1mL/kg body weight of 5% sodium taurocholate was retrogradely injected into the biliopancreatic duct of the rats to induce SAP associated lung injury.In treatment group,pentoxifylline was injected into caudal vein before 30min.Scores of pancrea... |
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| Keywords: | pancreatitis lung injury pentoxifylline cytokine |
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