| 大鼠静脉自身给药法观察盐酸二氢埃托啡的自身给药行为 |
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| 引用本文： | 王桂林,王卫平,哈鹰,郑继旺.大鼠静脉自身给药法观察盐酸二氢埃托啡的自身给药行为[J].中国药物依赖性杂志,1996(3). |
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| 作者姓名： | 王桂林 王卫平 哈鹰 郑继旺 |
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| 作者单位： | 北京医科大学中国药物依赖性研究所 |
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| 摘 要： | 本文用大鼠自身给药法初步评价了盐酸二氢埃托啡（ＤＨＥ）的精神依赖性，结果表明：在１．０，２．０和４．０μｇ·ｋｇ－１三个剂量下，ＤＨＥ均能形成稳定的自身给药行为，与吗啡相比，具有潜伏期短，反应阳性率高，踏板频率高等特点；提示ＤＨＥ的精神依赖性较强。
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| 关 键 词： | 静脉自身给药，盐酸二氢埃托啡，精神依赖性 |
INTRAVENOUS SELF - ADMINISTRATION OF DIHYDROETORPHINE IN RATS |
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| Wang Guilin, wang Weiping, Ha Ying, Zheng Jiwang.INTRAVENOUS SELF - ADMINISTRATION OF DIHYDROETORPHINE IN RATS[J].Chinese Journal of Drug Dependence,1996(3). |
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| Authors: | Wang Guilin wang Weiping Ha Ying Zheng Jiwang |
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| Abstract: | This experiment was designed to examine the psychological depen-dence potential of dihydroetorphine(DHE) by using intravenous self - administration inrats. Under a fixed - ratio 1 schedule the rats could maintain lever - press responding atdose of 1.0, 2.0 and 4.0 μg· kg-1/ injection of DHE. The rate of responding for DHEdecreased as the dose of DHE increased, while the total amount of DHE infusions wasproximately unchanged. Compared with morphine, DHE self - administration behaviorwas characterized by shorter latent period, higher ratio of positive responding and moreamount of lever - press, which indicated that DHE would likely have high psychologicaldependence potential. |
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| Keywords: | intravenous self - administration dihydroetorphine psychologicaldependence potential |
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