首页 | 本学科首页   官方微博 | 高级检索  
检索        


Integration of virtual and high-throughput screening
Authors:Bajorath Jürgen
Institution:Department of Computer-Aided Drug Discovery, Albany Molecular Research, Inc., Bothell Research Center, 18804 North Creek Parkway, Bothell, Washington 98011, USA. jurgen.bajorath@albmolecular.com
Abstract:High-throughput and virtual screening are important components of modern drug discovery research. Typically, these screening technologies are considered distinct approaches, as one is experimental and the other is theoretical in nature. However, given their similar tasks and goals, these approaches are much more complementary to each other than often thought. Various statistical, informatics and filtering methods have recently been introduced to foster the integration of experimental and in silico screening and maximize their output in drug discovery. Although many of these ideas and efforts have not yet proceeded much beyond the conceptual level, there are several success stories and good indications that early-stage drug discovery will benefit greatly from a more unified and knowledge-based approach to biological screening, despite the many technical advances towards even higher throughput that are made in the screening arena.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号