| 多发性硬化患者脑脊液一氧化氮水平的检测及意义 |
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| 引用本文： | 汪琦,文芳,万均成,肖玲.多发性硬化患者脑脊液一氧化氮水平的检测及意义[J].卒中与神经疾病,2004,11(5):286-288. |
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| 作者姓名： | 汪琦 文芳 万均成 肖玲 |
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| 作者单位： | 1. 430060,武汉大学人民医院神经内科
2. 武汉大学神经精神研究所 |
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| 摘 要： | 目的探讨多发性硬化患者脑脊液(CSF)一氧化氮(NO)含量变化.方法采用硝酸还原酶法检测43例多发性硬化(MS)患者、25例吉兰-巴雷综合症(GBS)患者及39例对照者CSF的NO水平,同时进行其生化和细胞学成分及寡克隆IgG区带(IgG-OB)分析.结果MS组CSF的NO水平明显高于对照组(P＜0.01).结论硝酸还原酶法能快速、准确地检测CSF的NO含量;NO参与了MS的免疫发病机制,并在一定程度上反映机体细胞免疫的状态.
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| 关 键 词： | 多发性硬化 脑脊液 一氧化氮 自身免疫 |
| 文章编号： | 1007-0478(2004)05-0286-03 |
Nitric Oxide in Cerebrospinal Fluid in Patient with Multiple Sclerosis |
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| Wang Qi,Wen Fang,Wan Juncheng,et al..Nitric Oxide in Cerebrospinal Fluid in Patient with Multiple Sclerosis[J].Stroke and Nervous Diseases,2004,11(5):286-288. |
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| Authors: | Wang Qi Wen Fang Wan Juncheng |
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| Institution: | Wang Qi,Wen Fang,Wan Juncheng,et al.Department of Neurology,Renmin Hospital of Wuhan University,Wuhan 430060 |
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| Abstract: | Objective To evaluate the relationship between the changes of concentrations of nitric oxide (NO) in cerebrospinal fluid (CSF) and the onset of multiple sclerosis (MS).Methods NO levels in CSF were detected in 43 cases of MS, 25 cases of Guillain Barre Syndrome (GBS), and 39 healthy people as control by using nitric reductase method.The biochemical and cytological components and oligoclonal IgG bands (IgG OB) in CSF were also examined.Results The levels of NO were significantly higher in MS group than control group.Conclusions NO may play an important role in the immune pathogenesis of MS and may reflect the behavior of cell mediated immunity. |
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| Keywords: | Multiple sclerosis Nitric oxide Erebrospinal fluid Autoimmunity |
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