| 乙吗噻嗪胃内滞留漂浮型缓释片的研究 |
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| 引用本文： | BM,Regmi,刘建平,屠锡德.乙吗噻嗪胃内滞留漂浮型缓释片的研究[J].药学学报,1996,31(1):54-58. |
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| 作者姓名： | BM Regmi 刘建平 屠锡德 |
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| 作者单位： | 中国药科大学药剂学教研室 |
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| 摘 要： | 研制了乙吗噻嗪胃内滞留漂浮型缓释片剂(E-HBS)。实验结果表明:本品的体外溶出符合一级动力学过程(Kr=0.2436h-1);人体胃内γ-闪烁照像显示E-HBS在胃内滞留时间长达6h以上,明显长于市售普通片(ECT1～1.5h);血药浓度经时曲线平缓持久,达到良好的缓释效果;体内外实验数据有显著的相关性(P<0.01)。
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| 关 键 词： | 乙吗噻嗪 缓释片 γ-闪烁照像术 药代动力学 |
| 收稿时间： | 1995-02-24 |
STUDIES ON ETHMOZINE SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACH |
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| BM Regmi,JP Liu and XD Tu.STUDIES ON ETHMOZINE SUSTAINED-RELEASE TABLET REMAINING-FLOATING IN STOMACH[J].Acta Pharmaceutica Sinica,1996,31(1):54-58. |
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| Authors: | BM Regmi JP Liu and XD Tu |
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| Abstract: | An oral sustained-release system of cthmozm0(E-HBS)was developed.The in vitro release characteristics of E-HBS were shown primarily to be of the first order of kinetics(Kr=0.2436h-1).The γ-scintiphotographic study showed that E-HBS remained in the human stomach formore than 6 hours after ingestion,much longer than the conventional tablet(1～1.5h).The plasmaconcentration-time curve of E-HBS exhibited typical sustained-release characteristics.The percentageof drug released in vitro vs the percentage of drug release in vivo of E-HBS indicated excellent linearity. |
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| Keywords: | Sustained release tablet γ-Scintiphoto technique Pharmacokinetics Ethmozine |
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