| 脑血康片对大鼠的长期毒性试验(II)——血液学及血液生化指标观察报告 |
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| 引用本文： | 李世相,朴晋华,张蕻.脑血康片对大鼠的长期毒性试验(II)——血液学及血液生化指标观察报告[J].山西中医学院学报,2001,2(4). |
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| 作者姓名： | 李世相 朴晋华 张蕻 |
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| 作者单位： | 1. 山西省医药规划设计院,山西,太原,030012
2. 山西省药品检验所,山西,太原,030001 |
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| 摘 要： | 目的 :研究脑血康片的长期毒性。方法 :用♀和♂大鼠进行口服给药 6 0天及恢复期 14天的毒性研究。结果 :研究期间未发生与试验药物相关的死亡 ,对大鼠体重、摄食量、一般行为没有明显影响 ;本品 1.35g/kg能减少血小板数和延长凝血时间 ,0 .6 75g/kg能延长雄鼠凝血时间和降低血小板数。停药 14天后 ,与对照组比较无显著性差异 ,其余指标与正常对照组比较均无显著性差异 ;血液生化学没有与试验药物相关的变化 ;心电图没有与药物相关的变化。结论 :脑血康片毒性较低 ,是一较安全的治疗药物
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| 关 键 词： | 脑血康片 大鼠 长期毒性 血液学 血液生化指标 |
The Chronic Toxicity Study on Nao Xue Kang(NXK, 脑血康) Tablets in Rats (Ⅱ)--A Observed Report on Hematology and Hemato- biochemical Index |
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| Li Shi Xiang et al..The Chronic Toxicity Study on Nao Xue Kang(NXK, 脑血康) Tablets in Rats (Ⅱ)--A Observed Report on Hematology and Hemato- biochemical Index[J].Journal of Shanxi College of Traditional Chinese Medicine,2001,2(4). |
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| Authors: | Li Shi Xiang |
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| Institution: | Shanxi Province Pharmaceutical Planning and Designig Institute .Taiyuan Shanxi 030012 |
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| Abstract: | Objective: To study the chronic toxicity of Nao Xue Kang(NXK, 脑血康)Tablets. Methods: ♀?♂rats received this drug by administering orally for 60 days.Its toxicity was recorded in the period and in 14 days of convalescence. Results: No death occurred.No apparent effects on the weight?diet and general behavior of rats were found.This drug (0.675g/kg) can reduce platelet amount and prolong coagulation time of male rats,and if its dosage is 1.35g/kg,it can have the same action to all rats.14 days after stopping this drug,there were no significant differences between two groups.No changes related to this drug were observed in hemato-biochemistry?electrocardiogram.There were also no significant differences in convalescence compared to controls. Conclusion: Nao Xue Kang(NXK, 脑血康) Tablets has a low toxicity, and it is safe and effective. |
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| Keywords: | Nao Xue Kang Tablets Rats Chronic toxicity Hematology Hemato-biochemical index |
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