| 术前急性高容量血液稀释对罗库溴铵量-效关系的影响 |
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| 引用本文： | 周桥灵,杨承祥,樊友凌,李恒,刘洪珍.术前急性高容量血液稀释对罗库溴铵量-效关系的影响[J].国际麻醉学与复苏杂志,2009,30(4):297-300. |
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| 作者姓名： | 周桥灵 杨承祥 樊友凌 李恒 刘洪珍 |
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| 作者单位： | 1. 中山大学附属佛山医院麻醉科,528000
2. 徐州医学院,江苏省麻醉医学研究所&江苏省麻醉学重点实验室 |
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| 摘 要： | Objective To study the influence of preoperative acute hypervolaemic haemodilution (AHHD) on the dose-response relationship of rocuronium.Methods Forty patients were randomly allocated to AHHD group or control group (n=20).Anesthesia was maintained with propofol and remifentsnyl using TCI,and rocuronium was randomly given with one of six doses(60 μg/kg).AHHD was conducted with preoperative infusion of 15 ml/kg 6% hydroxyethyl starch at a rate of 30 ml/min.Neuromuscular function was assessed using an accelograph with train-of-four stimulation at wrist.The dose-response relationship of rocuronium was determined with cumulative dose-response technique.Results Hb,Hct,TPP and ALB decreased markedly (P＜0.05) after AHHD.AHHD did not result in a significant shift in rocuronium dose-response curve.There was no significant difference in ED50,ED90,and ED95 between the AHHD group(192.1±24.9) μg/kg,(309.9±42.7) μg/kg,(322.0±44.4) μg/kg,respectively]and the control group (178.5±34.7) μg/kg,(209.1± 47.8)μg/kg,(304.1±49.5) μg/kg,respectively].Conclusion These results demonstrate that the potency of rocuronium is not affected by AHHD,and rocuronium may become an ideal choice of relaxant in occasion of applying AHHD.
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| 关 键 词： | 血液稀释 罗库溴铵 量-效关系 |
Influence of preoperative acute hypervolaemic haemodilution on the dose-response relationship of rocuronium |
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| Abstract: | Objective To study the influence of preoperative acute hypervolaemic haemodilution (AHHD) on the dose-response relationship of rocuronium.Methods Forty patients were randomly allocated to AHHD group or control group (n=20).Anesthesia was maintained with propofol and remifentsnyl using TCI,and rocuronium was randomly given with one of six doses(60 μg/kg).AHHD was conducted with preoperative infusion of 15 ml/kg 6% hydroxyethyl starch at a rate of 30 ml/min.Neuromuscular function was assessed using an accelograph with train-of-four stimulation at wrist.The dose-response relationship of rocuronium was determined with cumulative dose-response technique.Results Hb,Hct,TPP and ALB decreased markedly (P＜0.05) after AHHD.AHHD did not result in a significant shift in rocuronium dose-response curve.There was no significant difference in ED50,ED90,and ED95 between the AHHD group(192.1±24.9) μg/kg,(309.9±42.7) μg/kg,(322.0±44.4) μg/kg,respectively]and the control group (178.5±34.7) μg/kg,(209.1± 47.8)μg/kg,(304.1±49.5) μg/kg,respectively].Conclusion These results demonstrate that the potency of rocuronium is not affected by AHHD,and rocuronium may become an ideal choice of relaxant in occasion of applying AHHD. |
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| Keywords: | HaemodilutionRocuroniumDose-response relationship |
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