| 沙培林对鼠脑胶质瘤抑癌作用的实验研究 |
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| 引用本文： | 赵长地,颞振明,卢尚佩. 沙培林对鼠脑胶质瘤抑癌作用的实验研究[J]. 临床神经外科杂志, 2004, 1(3): 104-105 |
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| 作者姓名： | 赵长地 颞振明 卢尚佩 |
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| 作者单位： | 272111,山东省济宁市第一人民医院神经外科;272111,山东鲁抗医药集团鲁亚有限公司 |
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| 基金项目： | 山东省科委2001年立项课题 |
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| 摘 要： | 目的研究沙培林对裸鼠脑胶质瘤的抑癌作用。方法28只BALB/C裸小鼠皮下接种U251脑胶质瘤成功后随机分成4组,分别瘤周注射生理盐水0.2ml、沙培林0.2KE、0.4KE、0.8KE,共8次。解瘤实验,测量肿瘤的体积(V)和重量(W)。结果沙培林治疗组V与对照组V相比有明显差异(P<0.01和P<0.05),瘤重W经统计学处理亦有差异。治疗组抑瘤率分别为27.5%、32%和53.1%。结论沙培林可以抑制脑胶质瘤的生长。
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| 关 键 词： | 沙培林 脑胶质瘤 BALB/C裸鼠 抑癌作用 |
| 文章编号： | 1672-7770(2004)01-0104-02 |
| 修稿时间： | 2004-05-18 |
Experimental study on carcinostatic action of Sapylin for mouse with cerebral glioma |
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| Zhao Changdi,Nie Zhengming,Lu Shangpei. Experimental study on carcinostatic action of Sapylin for mouse with cerebral glioma[J]. Journal of Clinical Neurosurgery, 2004, 1(3): 104-105 |
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| Authors: | Zhao Changdi Nie Zhengming Lu Shangpei |
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| Affiliation: | Zhao Changdi,Nie Zheng-ming,Lu Shangpei. Department of Neurosurgery,the First People ' s Hospital of Jining,Shangdong Province,Jining 272111 |
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| Abstract: | Objective To study the carcinostatic action of Sapylin for mouse with cerebral glioma. Methods 28 postvaccinial BALB/C nude mouse with U251 glioma were randomly divided into 4 groups.0.2 ml normal saline solution,0. 2 KE Sapylin,0.4 KE Sapylin and 0.8 KE Sapylin were injected into periphery of tumors each group.The tumors were dissected after 8 times, then the volume and weight of all tumors were measured. Rusults The volume and weight of tumors in Sapylin groups were less than that in control group( P < 0.01, P < 0.05). The rates of inhibiting tumor in the Sapylin groups are 27.5 % , 32 % and 53.1% respectively. Conclusion Sapylin may inhibit the growth of cerebral glioma. |
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| Keywords: | Sapylin Cerebral glioma BALB/C nude mouse Carcinostatic action |
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