Functional classification of pituitary adenoma |
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| Authors: | Zhang Fulin Zhang Yulin Hu Jinxiu Wang Shanxiang Yang Detai |
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| Institution: | (1) Institute of Neurology, Huashan Hospital, Shanghai Medical University, Shanghai, China;(2) Department of Neurological Surgery, Huashan Hospital, Shanghai Medical University, Shanghai, China |
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| Abstract: | Pituitary adenoma may be calssified in light of the hormones produced. 225 surgical specimens were labeled with anti-sear
of GH, PRL. ACTH, TSH, FSH and LH by immunohistochemical technique (ABC method). Data indicated that 100 out of 225 cases
(44.5%) were monohormonal adenomas, including 24 GH, 39 PRL, 1 FSH and 9 LH, 77 (34.2%) were multi-hormonal adenomas, including
28 positive for 2 hormones, 30 positive for 3 hormones, 19 positive for 4 or more different hormones, and the remaining 48
(21.3%) were nonfunctional adenomas. In comparison with Kovacs series, factors which might participate in the mechanism of
developing monohormonal or multi-hormonal adenomas are discussed. |
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