| 12C离子束辐射选育庆大霉素高产菌株及其罐发酵水平 |
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| 引用本文： | 刘峰,傅袆,颜辉灿. 12C离子束辐射选育庆大霉素高产菌株及其罐发酵水平[J]. 中国抗生素杂志, 2003, 28(9): 517-519,554 |
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| 作者姓名： | 刘峰 傅袆 颜辉灿 |
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| 作者单位： | 1. 福建师范大学,生物工程学院,福州,350007
2. 福州抗生素集团有限公司,福州,350002 |
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| 摘 要： | 采用^12C离子束对庆大霉素产生菌23-18^#进行诱变，通过大量摇瓶筛选，选出5株进行2T罐中试，通过中试，选出2株高产变株在50T罐放大试验中发酵水平较出发菌株有重大突破，发酵水平及批总亿均提高10％以上。
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| 关 键 词： | 庆大霉素 ^12C离子束 发酵 高产变株 |
| 文章编号： | 1001-8689(2003)09-0517-03 |
Screening the high-yield mutants of gentamicin by 12C ion beam radiation and their productivity in fermentation tank |
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| Liu Feng,Fu Yi and Yan Hui-can. Screening the high-yield mutants of gentamicin by 12C ion beam radiation and their productivity in fermentation tank[J]. Chinese Journal of Antibiotics, 2003, 28(9): 517-519,554 |
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| Authors: | Liu Feng Fu Yi Yan Hui-can |
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| Affiliation: | Liu Feng1,Fu Yi2 and Yan Hui-can2 |
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| Abstract: | The gentamicin-producing strain 23-18# was radiated by 12C ion beam and obtained five mutants in shake flask test. By the pilot test in the tank of 2T, two production strains were selected. In comparison with the starting strains, the titers of these two production strains in 50T tank increased by over 10% in both fermentation performance and the overall yield. |
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| Keywords: | Gentamicin 12C ion beam Fermentation High-yield mutant |
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