| FHIT和PTEN基因与卵巢癌的相关性研究进展 |
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| 引用本文： | 陈衡,彭碧玲,黄海玉. FHIT和PTEN基因与卵巢癌的相关性研究进展[J]. 海南医学, 2009, 20(3): 104-108 |
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| 作者姓名： | 陈衡 彭碧玲 黄海玉 |
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| 作者单位： | 广东医学院附属深圳市福田区人民医院妇产科,广东,深圳,518033;广东医学院附属深圳市福田区人民医院妇产科,广东,深圳,518033;广东医学院附属深圳市福田区人民医院妇产科,广东,深圳,518033 |
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| 基金项目： | 深圳市福田区科技局公益性立项资助项目(FTWS001) |
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| 摘 要： | FHIT基因是在染色体3p14．2上找到的一个候选抑癌基因，在多种恶性肿瘤组织中表达异常；PTEN基因是迄今发现的第一个具有双特异性磷酸酶活性的抑癌基因，该基因的突变失活与人类多数恶性肿瘤的发生、发展密切相关。现就FHIT、PTEN基因与卵巢癌的关系研究进展加以综述。
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| 关 键 词： | FHIT PTEN 抑癌基因 卵巢癌 |
Associated study progresses of gene FHIT and PTEN in ovarian cancer |
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| CHEN Heng,PENG Biling,HUANG Haiyu. Associated study progresses of gene FHIT and PTEN in ovarian cancer[J]. Hainan Medical Journal, 2009, 20(3): 104-108 |
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| Authors: | CHEN Heng PENG Biling HUANG Haiyu |
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| Affiliation: | ( Department of Obstetrics and Gynecology, the Affiliated Shenzhen Futian People＇ s Hospital of Guangdong Medical College, Shenzhen 518033, Guangdong , P. R. CHINA) |
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| Abstract: | FHIT was a candidate tumor suppressor gene whic is located in chromosome 3p14.2. It has found abnormal in multiple malignancies frequently. PTEN was the first tumor suppressor gene with double specific phosphatase activity. Its mutation and inactivation are related to the genesis, development and progression of many human tumors. This article reviews progresses about the relationship of gene FHIT as well as PTEN with ovarian cancer respectively. |
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| Keywords: | FHIT PTEN Tumor suppressor gene Ovarian cancer |
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