| Smad与肺纤维化 |
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| 引用本文： | 曹汐汐,许祖德. Smad与肺纤维化[J]. 国际病理科学与临床杂志, 2006, 26(6): 7-494 |
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| 作者姓名： | 曹汐汐 许祖德 |
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| 作者单位： | 复旦大学上海医学院病理学系,上海,200032;复旦大学上海医学院病理学系,上海,200032 |
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| 摘 要： | 转化生长因子β(TGF-β) 是与肺纤维化关系较为密切的细胞因子。Smad蛋白为TGF-β受体后下游的主要信号转导因子,其中Smad3是纤维化疾病的重要介导者,Smad7是TGF-β信号转导途径的主要抑制性蛋白,它们的异常表达可影响TGF-β活性,进而改变纤维化进程。调控Smad3，Smad7的表达可能为治疗纤维化疾病提供一种新手段。
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| 关 键 词： | Smad蛋白 转化生长因子β 肺纤维化 |
| 文章编号： | 1673-2588(2006)06-0488-07 |
| 收稿时间： | 2006-07-10 |
| 修稿时间： | 2006-07-10 |
Smads and pulmonary fibrosis |
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| CAO Xi-xi,XU Zu-de. Smads and pulmonary fibrosis[J]. Journal of International Pathology and Clinical Medicine, 2006, 26(6): 7-494 |
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| Authors: | CAO Xi-xi XU Zu-de |
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| Affiliation: | Department of Pathology, Shanghai Medical College of Fudan University, Shanghai 200032, China |
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| Abstract: | Transforming growth factor-β(TGF-β) plays a central role in pulmonary fibrosis. The Smads act the downstream of receptors for the transforming growth factor-β family of ligands, among which Smad3 functions as a mediator of fibrotic disorder, while Smad7 is a major inhibitory regular in TGF-β signaling pathway. The abnormal expression of Smad3 or Smad7 can affect the activity of TGF-β and accordingly change the process of fibrosis. The modulation of Smad3 or Smad7 expression may have tremendous clinical potential in therapeutic strategy for fibrotic diseases. |
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| Keywords: | Smads TGF-β pulmonary fibrosis |
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